硅橡胶基质：细胞运动研究中的一个新难题。

Silicone rubber substrata: a new wrinkle in the study of cell locomotion.

作者信息

Harris A K, Wild P, Stopak D

出版信息

Science. 1980 Apr 11;208(4440):177-9. doi: 10.1126/science.6987736.

Abstract

When tissue cells are cultured on very thin sheets of cross-linked silicone fluid, the traction forces the cells exert are made visible as elastic distortion and wrinkling of this substratum. Around explants this pattern of wrinkling closely resembles the "center effects" long observed in plasma clots and traditionally attributed to dehydration shrinkage.

摘要

当组织细胞在非常薄的交联硅酮流体片上培养时，细胞施加的牵引力会使这种基质发生弹性变形和起皱，从而变得可见。在外植体周围，这种起皱模式与长期以来在血浆凝块中观察到的“中心效应”非常相似，传统上认为这是脱水收缩所致。