脉冲电场消融诱导抗肿瘤免疫反应的研究进展
[Research advances of anti-tumor immune response induced by pulse electric field ablation].
作者信息
Cui Guang-ying, Diao Hong-yan
机构信息
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Nov;44(6):672-7. doi: 10.3785/j.issn.1008-9292.2015.11.12.
As a novel tumor therapy, pulse electric field has shown a clinical perspective. This paper reviews the characteristics of tumor ablation by microsecond pulse and nanosecond pulse electric field, and the research advances of anti-tumor immune response induced by pulse electric field ablation. Recent researches indicate that the pulse electric field not only leads to a complete ablation of local tumor, but also stimulates a protective immune response, thereby inhibiting tumor recurrence and metastasis. These unique advantages will show an extensive clinical application in the future. However, the mechanism of anti-tumor immune response and the development of related tumor vaccine need further studies.
作为一种新型肿瘤治疗方法，脉冲电场已展现出临床应用前景。本文综述了微秒级脉冲和纳秒级脉冲电场肿瘤消融的特点，以及脉冲电场消融诱导抗肿瘤免疫反应的研究进展。近期研究表明，脉冲电场不仅能实现局部肿瘤的完全消融，还能激发保护性免疫反应，从而抑制肿瘤复发和转移。这些独特优势未来将展现出广泛的临床应用前景。然而，抗肿瘤免疫反应机制及相关肿瘤疫苗的研发仍需进一步研究。
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