[纳秒级脉冲电场消融机制]
[Mechanism of ablation with nanosecond pulsed electric field].
作者信息
Cen Chao, Chen Xin-hua, Zheng Shu-sen
机构信息
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Nov;44(6):678-83. doi: 10.3785/j.issn.1008-9292.2015.11.13.
Nanosecond pulsed electric field ablation has been widely applied in clinical cancer treatment, while its molecular mechanism is still unclear. Researchers have revealed that nanosecond pulsed electric field generates nanopores in plasma membrane, leading to a rapid influx of Ca²⁺; it has specific effect on intracellular organelle membranes, resulting in endoplasmic reticulum injuries and mitochondrial membrane potential changes. In addition, it may also change cellular morphology through damage of cytoskeleton. This article reviews the recent research advances on the molecular mechanism of cell membrane and organelle changes induced by nanosecond pulsed electric field ablation.
纳秒级脉冲电场消融已广泛应用于临床癌症治疗，但其分子机制仍不清楚。研究人员发现，纳秒级脉冲电场可在质膜上产生纳米孔，导致Ca²⁺快速内流；它对细胞内膜细胞器有特定作用，导致内质网损伤和线粒体膜电位变化。此外，它还可能通过损伤细胞骨架改变细胞形态。本文综述了纳秒级脉冲电场消融诱导细胞膜和细胞器变化的分子机制的最新研究进展。
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