Lee Yoo-Kyung, Chung Hyun Hoon, Kim Jae Weon, Song Yong-Sang, Park Noh-Hyun
Department of Obstetrics and Gyneocology, Cheil General Hospital, College of Medicine, Dankook University Seoul, Korea.
Department of Obstetrics and Gynecology, Seoul National University Hospital, College of Medicine, Seoul National University Seoul, Korea.
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14971-6. eCollection 2015.
Activation of human telomere reverse transcriptase (hTERT) is associated with the tumorigenic role of Akt. We aimed to evaluate the significance of Akt phosphorylation and hTERT expression on the prognosis of epithelial ovarian cancer (EOC). Between 2005 and 2012, 92 EOC patients treated at the Seoul National University Hospital were included in this study. Paraffin-embedded sections from the tumors of EOC patients were stained with anti-hTERT and anti-phosphorylated Akt (pAkt) antibodies. Correlations of pAkt and hTERT expression with the clinicopathological factors were analyzed using SPSS software, version 17.0 (IBM, Chicago, IL, USA). In 92 EOC tissues, pAkt and hTERT were not associated with any clinicopathological factors. However, the disease-free survival rate of patients exhibiting coexpression of pAkt and hTERT was poor compared with that of the other patients (P = 0.013). Coexpression of pAkt and hTERT is a poor prognostic marker for EOC.
人端粒逆转录酶（hTERT）的激活与Akt的致瘤作用相关。我们旨在评估Akt磷酸化和hTERT表达对上皮性卵巢癌（EOC）预后的意义。2005年至2012年期间，本研究纳入了92例在首尔国立大学医院接受治疗的EOC患者。用抗hTERT和抗磷酸化Akt（pAkt）抗体对EOC患者肿瘤的石蜡包埋切片进行染色。使用SPSS 17.0软件（美国伊利诺伊州芝加哥市IBM公司）分析pAkt和hTERT表达与临床病理因素的相关性。在92例EOC组织中，pAkt和hTERT与任何临床病理因素均无关联。然而，与其他患者相比，pAkt和hTERT共表达患者的无病生存率较差（P = 0.013）。pAkt和hTERT共表达是EOC预后不良的标志物。
