Wan Peng-Zhi, Han Qiang, Wang En-Hua, Lin Xu-Yong
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15402-6. eCollection 2015.
Glomus tumor is an uncommon tumor usually presenting in the dermis. Rarely, it occurred in visceral organs including stomach, liver and long. The majority of glomus tumors were benign. Herein, we present a case of glomus tumor located in the left lobe of the lung in a 49 year-old Chinese male. An irregular mass measuring 3 cm was detected by imaging examination because of his suffering from cough, dyspnea and chest pain. Histologically, the tumor is composed predominantly of sheets of ovoid to round cells with clear border, pale cytoplasm and fine granular chromatin. The mitotic count was less than 5 per 50 HPF. The tumor focally invaded the surrounding normal bronchial and alveolar tissue. Immunohistochemical staining showed that the cells were diffusely positive for SMA, caldesmon, and vimentin. The Ki-67 proliferation index was approximately 20%. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with glomus tumor of uncertain malignant potential.
血管球瘤是一种罕见的肿瘤，通常出现在真皮层。很少发生在内脏器官，包括胃、肝脏和肺。大多数血管球瘤是良性的。在此，我们报告一例49岁中国男性患者，其血管球瘤位于左肺叶。由于他患有咳嗽、呼吸困难和胸痛，影像学检查发现一个3厘米的不规则肿块。组织学上，肿瘤主要由卵圆形至圆形细胞片组成，细胞边界清晰，细胞质淡染，染色质呈细颗粒状。每50个高倍视野有丝分裂计数少于5个。肿瘤局部侵犯周围正常支气管和肺泡组织。免疫组化染色显示细胞平滑肌肌动蛋白（SMA）、钙调蛋白和波形蛋白弥漫性阳性。Ki-67增殖指数约为20%。根据形态学特征和免疫组化结果，该肿瘤符合恶性潜能不确定的血管球瘤。
