Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey.
Basic Clin Androl. 2016 Jan 28;26:1. doi: 10.1186/s12610-015-0028-x. eCollection 2016.
Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED.
All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated.
The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01).
In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.
内皮功能障碍和微血管损伤在勃起功能障碍（ED）的发病机制中起着关键作用。胰岛素样生长因子-1（IGF-1）是具有广泛生物学效应的生长因子之一。IGF-1 是各种组织中细胞生长、分化和转化的重要介质。本研究的目的是确定 IGF-1 水平与 ED 之间的关系。
所有男性均接受 ED 评估，并分为两组：80 例 ED 患者，病程>1 年；80 例无 ED 患者作为对照组。ED 的诊断基于国际勃起功能指数评分-5。采用自动化化学发光免疫分析法测定血清 IGF-1 水平。统计分析 IGF-1 水平与患者 ED 评分之间的关系。
ED 组患者的平均年龄为 60.4±11.3 岁，对照组为 55.4±9.6 岁。ED 组患者的 IGF-1 水平明显低于对照组（分别为 96.5±38.3 和 132.5±53.3ng/ml，P<0.001）。IGF-1 水平与 ED 评分呈正相关（r=0.623，P<0.01）。
本研究发现血清 IGF-1 水平与预测 ED 的内皮功能障碍有关。血清 IGF-1 水平似乎是 ED 的特异性预测指标，可用于男性 ED 的早期预测。
