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雾化戊烷脒用于肾移植受者预防肺孢子菌肺炎是否不像我们想象的那么安全?

Is Aerosolized Pentamidine for Pneumocystis Pneumonia Prophylaxis in Renal Transplant Recipients Not as Safe as We Might Think?

作者信息

Macesic N, Urbancic K, Ierino F, Grayson M L

机构信息

Department of Infectious Diseases, Austin Health, Melbourne, Australia Division of Infectious Diseases, Columbia University Medical Center, New York, New York, USA

Department of Infectious Diseases, Austin Health, Melbourne, Australia.

出版信息

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2502-4. doi: 10.1128/AAC.02290-15. Print 2016 Apr.

Abstract

Outbreaks ofPneumocystispneumonia have been described in renal transplant recipients. Aerosolized pentamidine is frequently used for prophylaxis in this setting. We report our experience with aerosolized pentamidine use in 56 renal transplant recipients. We found high rates of adverse reactions in patients with chronic respiratory disease.

摘要

肾移植受者中曾有卡氏肺孢子虫肺炎暴发的报道。雾化喷他脒常用于此情况下的预防。我们报告了56例肾移植受者使用雾化喷他脒的经验。我们发现慢性呼吸道疾病患者的不良反应发生率很高。

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J Infect. 2009 Mar;58(3):248-50. doi: 10.1016/j.jinf.2009.01.009. Epub 2009 Feb 26.

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