简短报告：抗逆转录病毒治疗对HIV-2感染患者巨噬细胞活化的影响较小——HIV-1、HIV-2及HIV-1/2双重感染患者中的可溶性CD163

Brief Report: Macrophage Activation in HIV-2-Infected Patients Is Less Affected by Antiretroviral Treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients.

作者信息

Hønge Bo L, Andersen Morten N, Jespersen Sanne, Medina Candida, Correira Faustino G, Jakobsen Martin R, Laursen Alex, Erikstrup Christian, Møller Holger J, Wejse Christian

机构信息

*Department of Clinical Immunology, Aarhus University Hospital, Denmark;†Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau;Departments of ‡Infectious Diseases;§Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark;‖Department of Biomedicine, Aarhus University, Denmark;¶National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau; and#GloHAU, Center for Global Health, School of Public Health, Aarhus University, Aarhus, Denmark.

出版信息

J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):254-8. doi: 10.1097/QAI.0000000000000939.

DOI:10.1097/QAI.0000000000000939

PMID:26825178

Abstract

The course of disease among HIV-2, HIV-1, and HIV-1/2 dually infected patients is different. We investigated the macrophage activation marker soluble CD163 (sCD163) dynamics in 212 HIV-1, HIV-2, and HIV-1/2 dually infected patients. There were no differences in sCD163 levels at baseline or during follow-up without antiretroviral therapy (ART). At follow-up on ART, median sCD163 levels were decreased for HIV-1-infected patients (P < 0.001), but not among HIV-2 (P = 0.093) or HIV-1/2 dually infected patients (P = 0.145). The larger decrease in sCD163 levels among HIV-1-infected patients during ART may indicate an HIV type-dependent differential effect of ART on macrophage activation during HIV infection.

摘要

HIV-2、HIV-1以及HIV-1/2双重感染患者的病程有所不同。我们调查了212例HIV-1、HIV-2以及HIV-1/2双重感染患者体内巨噬细胞活化标志物可溶性CD163（sCD163）的动态变化。在未接受抗逆转录病毒治疗（ART）时，基线或随访期间的sCD163水平并无差异。在接受ART随访时，HIV-1感染患者的sCD163水平中位数有所下降（P < 0.001），但HIV-2感染患者（P = 0.093）以及HIV-1/2双重感染患者（P = 0.145）的sCD163水平并未下降。HIV-1感染患者在ART期间sCD163水平下降幅度更大，这可能表明在HIV感染期间，ART对巨噬细胞活化的影响存在HIV类型依赖性差异。