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轴丝：精子和纤毛的推进引擎以及导致不育的相关纤毛病。

The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility.

作者信息

Linck Richard W, Chemes Hector, Albertini David F

机构信息

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, 55455, USA.

Center for Research in Endocrinology, National Research Council, CEDIE-CONICET, Endocrinology Division, Buenos Aires Children's Hospital, Gallo 1330, C1425SEFD, Buenos Aires, Argentina.

出版信息

J Assist Reprod Genet. 2016 Feb;33(2):141-56. doi: 10.1007/s10815-016-0652-1. Epub 2016 Jan 29.

DOI:10.1007/s10815-016-0652-1
PMID:26825807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4759005/
Abstract

This review article provides a critical analysis of the structure and molecular mechanisms of the microtubule axoneme of cilia and sperm flagella and their associated elements required for male fertility.A broad range of genetic and molecular defects (ciliopathies) are considered in the context of human diseases involving impaired motility in cilia and sperm flagella, providing provocative thought for future research in the area of male infertility.

摘要

这篇综述文章对纤毛和精子鞭毛的微管轴丝的结构和分子机制，以及男性生育所需的相关成分进行了批判性分析。在涉及纤毛和精子鞭毛运动受损的人类疾病背景下，考虑了广泛的遗传和分子缺陷（纤毛病），为男性不育领域的未来研究提供了引人深思的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/42a5d8cf039c/10815_2016_652_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/3f8ef36219ee/10815_2016_652_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/b6e1ff137998/10815_2016_652_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/16be1e404dd3/10815_2016_652_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/fe9061e26f9d/10815_2016_652_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/5a4e4d1607ea/10815_2016_652_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/a96de8564683/10815_2016_652_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/42a5d8cf039c/10815_2016_652_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/3f8ef36219ee/10815_2016_652_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/b6e1ff137998/10815_2016_652_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/16be1e404dd3/10815_2016_652_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/fe9061e26f9d/10815_2016_652_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/5a4e4d1607ea/10815_2016_652_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/a96de8564683/10815_2016_652_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c38b/4759005/42a5d8cf039c/10815_2016_652_Fig7_HTML.jpg

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