Amson R, Sigaux F, Przedborski S, Flandrin G, Givol D, Telerman A
Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Belgium.
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8857-61. doi: 10.1073/pnas.86.22.8857.
We measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies. Our data indicate that during human fetal hematopoiesis the 33-kDa pim product, p33pim, is highly expressed in the liver and spleen. In contrast, at the adult stage it is only slightly expressed in circulating granulocytes. Out of 70 hematopoietic malignancies analyzed, 51 patients and 19 cell lines, p33pim was overexpressed in approximately 30% of the samples, particularly in myeloid and lymphoid acute leukemias. This overexpression was unrelated to any stage of cellular differentiation and was not due to gene rearrangement or amplification. These results imply a physiological role of the pim-1 protooncogene during hematopoietic development and a deregulation in various leukemias.
我们检测了人类原癌基因pim-1（PIM）在胎儿发育过程及造血系统恶性肿瘤中的表达情况。我们的数据表明，在人类胎儿造血过程中，33 kDa的pim产物p33pim在肝脏和脾脏中高表达。相比之下，在成人阶段，它仅在循环粒细胞中略有表达。在分析的70例造血系统恶性肿瘤（51例患者和19个细胞系）中，约30%的样本中p33pim过表达，尤其在髓系和淋巴系急性白血病中。这种过表达与细胞分化的任何阶段均无关，也不是由基因重排或扩增所致。这些结果提示pim-1原癌基因在造血发育过程中具有生理作用，且在各种白血病中存在失调。
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