Julson Janet Rae, Marayati Raoud, Beierle Elizabeth Ann, Stafman Laura Lee
Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Division of Pediatric Surgery, Department of Surgery, Vanderbilt University, Nashville, TN 37240, USA.
Cancers (Basel). 2022 Jul 22;14(15):3565. doi: 10.3390/cancers14153565.
PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.
PIM激酶已被确定为多种恶性肿瘤的潜在治疗靶点。在此，我们对PIM激酶进行了深入综述，包括它们的结构、表达、活性、调控及其在儿科肿瘤发生中的作用。还简要总结了目前可用的靶向PIM激酶的药物制剂和现有临床试验。
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