Möller Christiane, Hafkemeijer Anne, Pijnenburg Yolande A L, Rombouts Serge A R B, van der Grond Jeroen, Dopper Elise, van Swieten John, Versteeg Adriaan, Steenwijk Martijn D, Barkhof Frederik, Scheltens Philip, Vrenken Hugo, van der Flier Wiesje M
Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
Institute of Psychology, Leiden University, Leiden, the Netherlands; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Neurobiol Aging. 2016 Feb;38:21-31. doi: 10.1016/j.neurobiolaging.2015.10.020. Epub 2015 Oct 30.
We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year. Decrease of thickness over time was highest in AD and generalized throughout the whole brain, most pronounced posteriorly, whereas bvFTD patients had a more selective loss in frontal cortex and in anterior parts of the temporal lobes. In a direct comparison, AD patients showed faster cortical thinning in the insula, temporal, and parietal regions, whereas bvFTD patients only showed faster cortical thinning in the orbitofrontal gyrus. Decline of cognitive performances was in line with cortical thinning and deteriorated the most in AD patients.
我们对19例阿尔茨海默病（AD）患者、10例行为变异型额颞叶痴呆（bvFTD）患者和34名对照者进行了研究，观察随着时间推移皮质厚度损失和认知衰退的模式，平均间隔时间为2.1±0.4年。我们使用纵向FreeSurfer管道测量了各组之间6个感兴趣叶区域的顶点和区域皮质厚度变化。与对照组相比，AD和bvFTD的认知衰退速度更快，且每年皮质变薄速度更快。AD患者随时间推移的厚度下降最高，且在全脑普遍存在，后部最为明显，而bvFTD患者在额叶皮质和颞叶前部有更具选择性的损失。在直接比较中，AD患者在岛叶、颞叶和顶叶区域的皮质变薄更快，而bvFTD患者仅在眶额回显示出更快的皮质变薄。认知表现的衰退与皮质变薄一致，且在AD患者中恶化最为严重。
