小脑功能障碍与睡眠障碍的叙述性综述
A Narrative Review of Cerebellar Malfunctions and Sleep Disturbances.
作者信息
Song Bijia, Zhu Jun-Chao
机构信息
Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Anesthesiology, Beijing Friendship Hospital of Capital Medical University, Beijing, China.
出版信息
Front Neurosci. 2021 Jun 25;15:590619. doi: 10.3389/fnins.2021.590619. eCollection 2021.
Abstract
Cerebellar malfunctions significantly impact the regulation of the sleep-wakefulness transition. The possible mechanism for this effect is still unknown. Evidence on the role of cerebellar processing in the sleep-wake cycle is derived mainly from animal studies, and clinical management of the sleep-wake cycle is also challenging. The purpose of this review is to investigate the role of cerebellar activity during normal sleep and the association between cerebellar dysfunction and sleep disorders. Large-scale, multicenter trials are still needed to confirm these findings and provide early identification and intervention strategies to improve cerebellar function and the sleep quality of patients.
摘要
小脑功能障碍会显著影响睡眠-觉醒转换的调节。这种影响的可能机制尚不清楚。关于小脑处理在睡眠-觉醒周期中作用的证据主要来自动物研究，并且睡眠-觉醒周期的临床管理也具有挑战性。本综述的目的是研究正常睡眠期间小脑活动的作用以及小脑功能障碍与睡眠障碍之间的关联。仍需要大规模、多中心试验来证实这些发现，并提供早期识别和干预策略，以改善小脑功能和患者的睡眠质量。
相似文献
1
A Narrative Review of Cerebellar Malfunctions and Sleep Disturbances.小脑功能障碍与睡眠障碍的叙述性综述
Front Neurosci. 2021 Jun 25;15:590619. doi: 10.3389/fnins.2021.590619. eCollection 2021.
2
Cerebellar malfunction and postoperative sleep disturbances after general anesthesia: a narrative review.小脑功能障碍与全身麻醉后睡眠障碍：叙述性综述。
Sleep Breath. 2022 Mar;26(1):31-36. doi: 10.1007/s11325-021-02361-9. Epub 2021 May 14.
3
A narrative review of the impact of cerebellar dysfunction and sleep disturbances after general anesthesia in patients with Alzheimer's disease.对阿尔茨海默病患者全身麻醉后小脑功能障碍和睡眠障碍影响的叙述性综述。
Ann Palliat Med. 2021 Jun;10(6):6919-6925. doi: 10.21037/apm-20-2597. Epub 2021 Apr 23.
4
Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat.与睡眠/觉醒状态相关的脑电图微观结构和转换结构的拓扑学区分了大鼠中功能上不同的胆碱能神经支配障碍。
Behav Brain Res. 2013 Nov 1;256:108-18. doi: 10.1016/j.bbr.2013.07.047. Epub 2013 Aug 6.
5
Cardiovascular and respiratory profiles during the sleep-wake cycle of rats previously submitted to chronic intermittent hypoxia.在先前经历慢性间歇性低氧的大鼠的睡眠-觉醒周期期间的心血管和呼吸特征。
Exp Physiol. 2019 Sep;104(9):1408-1419. doi: 10.1113/EP087784. Epub 2019 Jun 2.
6
Slow potential shifts at sleep--wake transitions and shifts between NREM and REM sleep.睡眠-觉醒转换以及非快速眼动睡眠和快速眼动睡眠之间转换时的缓慢电位变化。
Sleep. 1996 Feb;19(2):145-51. doi: 10.1093/sleep/19.2.145.
7
[Selective stimulations and lesions of the rat brain nuclei as the models for research of the human sleep pathology mechanisms].[选择性刺激和损伤大鼠脑核作为研究人类睡眠病理机制的模型]
Glas Srp Akad Nauka Med. 2011(51):85-97.
8
Lesion of the pedunculopontine tegmental nucleus in rat augments cortical activation and disturbs sleep/wake state transitions structure.大鼠脑桥被盖脚核损伤增强皮质激活并扰乱睡眠/觉醒状态转换结构。
Exp Neurol. 2013 Sep;247:562-71. doi: 10.1016/j.expneurol.2013.02.007. Epub 2013 Feb 26.
9
Circadian rhythms and sleep have additive effects on respiration in the rat.昼夜节律和睡眠对大鼠的呼吸有叠加效应。
J Physiol. 2001 Oct 1;536(Pt 1):225-35. doi: 10.1111/j.1469-7793.2001.00225.x.
10
[Neurochemical mechanisms of sleep regulation].[睡眠调节的神经化学机制]
Glas Srp Akad Nauka Med. 2009(50):97-109.
引用本文的文献
1
GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies.通过减法进行全基因组关联研究以从α-突触核蛋白病中解析出RBD的遗传背景。
Int J Mol Sci. 2025 Apr 10;26(8):3578. doi: 10.3390/ijms26083578.
2
Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.阿尔茨海默病及其他神经退行性疾病中的小脑：一个新兴的研究前沿。
MedComm (2020). 2024 Jul 13;5(7):e638. doi: 10.1002/mco2.638. eCollection 2024 Jul.
3
Purkinje cell dysfunction causes disrupted sleep in ataxic mice.浦肯野细胞功能障碍导致共济失调小鼠睡眠紊乱。
Dis Model Mech. 2024 Jun 1;17(6). doi: 10.1242/dmm.050379. Epub 2024 Jun 12.
4
Subcortical and default mode network connectivity is impaired in myalgic encephalomyelitis/chronic fatigue syndrome.肌痛性脑脊髓炎/慢性疲劳综合征患者的皮质下和默认模式网络连接受损。
Front Neurosci. 2024 Jan 29;17:1318094. doi: 10.3389/fnins.2023.1318094. eCollection 2023.
5
Evaluation of cellular activity in response to sleep deprivation by a comprehensive analysis of the whole mouse brain.通过对整个小鼠大脑的综合分析评估细胞对睡眠剥夺的反应活性。
Front Neurosci. 2023 Oct 19;17:1252689. doi: 10.3389/fnins.2023.1252689. eCollection 2023.
6
Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging.睡眠剥夺加重淀粉样β寡聚体对大鼠小脑的损伤：来自磁共振成像的证据。
Aging Brain. 2023 Aug 5;4:100091. doi: 10.1016/j.nbas.2023.100091. eCollection 2023.
7
A voxel-based morphometry investigation of brain structure variations in late-life depression with insomnia.一项基于体素的形态测量学研究：老年期伴有失眠的抑郁症患者的脑结构变化
Front Psychiatry. 2023 May 18;14:1201256. doi: 10.3389/fpsyt.2023.1201256. eCollection 2023.
8
Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.肌张力障碍中小脑功能障碍与睡眠障碍之间的潜在相互作用。
Dystonia. 2022 Oct;1. doi: 10.3389/dyst.2022.10691. Epub 2022 Oct 4.
9
What Is the Involvement of the Cerebellum During Sleep?睡眠期间小脑有何作用？
Neurology. 2023 Mar 21;100(12):572-577. doi: 10.1212/WNL.0000000000207161.
10
The Mediatory Role of Executive Functioning on the Association Between Sleep and Both Everyday Memory and ADHD Symptoms in Children and Youth With Down Syndrome.执行功能在睡眠与唐氏综合征儿童和青少年日常记忆及 ADHD 症状之间的关联中的中介作用。
Am J Intellect Dev Disabil. 2023 Jan 1;128(1):82-95. doi: 10.1352/1944-7558-128.1.82.
本文引用的文献
1
Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.小鼠在睡眠-觉醒转换期间小脑的神经元活动。
Neurosci Bull. 2020 Aug;36(8):919-931. doi: 10.1007/s12264-020-00511-9. Epub 2020 May 19.
2
Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing.小脑功能丧失选择性地影响正常呼吸的固有节律性。
Biol Open. 2020 Apr 13;9(4):bio048785. doi: 10.1242/bio.048785.
3
Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease.睡眠障碍作为帕金森病的潜在风险和进展因素。
J Parkinsons Dis. 2019;9(3):603-614. doi: 10.3233/JPD-191627.
4
Cerebellar Control of Reach Kinematics for Endpoint Precision.小脑控制末端精度的运动学。
Neuron. 2019 Jul 17;103(2):335-348.e5. doi: 10.1016/j.neuron.2019.05.007. Epub 2019 Jun 4.
5
Association between circadian rhythms and neurodegenerative diseases.昼夜节律与神经退行性疾病的关系。
Lancet Neurol. 2019 Mar;18(3):307-318. doi: 10.1016/S1474-4422(18)30461-7. Epub 2019 Feb 12.
6
Implications of sleep disturbance and inflammation for Alzheimer's disease dementia.睡眠障碍和炎症对阿尔茨海默病痴呆的影响。
Lancet Neurol. 2019 Mar;18(3):296-306. doi: 10.1016/S1474-4422(18)30450-2. Epub 2019 Jan 17.
7
A cortico-cerebellar loop for motor planning.大脑皮层-小脑环路用于运动规划。
Nature. 2018 Nov;563(7729):113-116. doi: 10.1038/s41586-018-0633-x. Epub 2018 Oct 17.
8
The Cerebello-Hypothalamic and Hypothalamo-Cerebellar Pathways via Superior and Middle Cerebellar Peduncle in the Rat.大鼠中脑小脑脚和中脑小脑脚通过上脑桥和中脑桥的小脑下丘脑和下丘脑小脑通路。
Cerebellum. 2018 Oct;17(5):517-524. doi: 10.1007/s12311-018-0938-1.
9
Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.小脑蚓部浦肯野细胞向中脑臂旁核的直接投射的解剖学证据。
Front Neural Circuits. 2018 Feb 7;12:6. doi: 10.3389/fncir.2018.00006. eCollection 2018.
10
Treatment guidelines for Circadian Rhythm Sleep-Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part I. Physiology, assessment and therapeutic methods.波兰睡眠研究学会和波兰精神病学协会生物精神病学分会昼夜节律性睡眠-觉醒障碍治疗指南。第一部分。生理学、评估与治疗方法。
Psychiatr Pol. 2017 Oct 29;51(5):793-814. doi: 10.12740/PP/OnlineFirst/66810.
Zotero 插件