马洛托皂苷B和C：全合成、抗寄生虫评估及初步构效关系研究
Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies.
作者信息
Grayfer Tatyana D, Grellier Philippe, Mouray Elisabeth, Dodd Robert H, Dubois Joëlle, Cariou Kevin
机构信息
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud , Univ. Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France.
UMR 7245 CNRS, Département RDDM, Muséum National d'Histoire Naturelle CP52 , 57 Rue Cuvier, 75005 Paris, France.
出版信息
Org Lett. 2016 Feb 19;18(4):708-11. doi: 10.1021/acs.orglett.5b03676. Epub 2016 Feb 1.
PMID:26828239
Abstract
The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.
摘要
首次完成了马洛托日本皂苷B和C以及几种类似物的全合成。还对合成化合物针对恶性疟原虫和布氏锥虫进行了生物学评价。
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