School of Life Science, Ludong University, Yantai, Shandong, China.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1027-1044. doi: 10.1080/14756366.2020.1732366.
As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.
作为世界五大绝症之一，肿瘤会导致重要的遗传功能障碍。然而，目前一些治疗肿瘤的药物通常具有较强的毒副作用，并且容易产生耐药性。研究发现，从天然物质中提取的法呢基转移酶抑制剂（FTIs）对肿瘤具有良好的抑制作用，副作用较少。本文介绍了几种从天然物质中提取的 FTIs，并阐明了当前的研究进展，为肿瘤的治疗提供了新的选择。
