a Department of Surgery , "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology , Cluj Napoca , Romania .
b Department of Surgery , "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology; Anatomy and Embryology Department, UMF "Iuliu Haţieganu" , Cluj-Napoca , Romania .
Drug Metab Rev. 2016;48(1):27-46. doi: 10.3109/03602532.2015.1130052. Epub 2016 Feb 1.
Colorectal cancer is a major public health issue, being the third most common cancer in men and the second in women. It is one of the leading causes of cancer deaths. Nanomedicine is an emerging field of interest, many of its aspects being linked to cancer research. Chemotherapy has a well-established role in colorectal cancer management, unfortunately being limited by inability to have a selective distribution, by multidrug resistance and adverse effects. Researches carried out in recent years about nanotechnologies aimed, among others, to resolve the issues mentioned above. Targeted and localized delivery of the chemotherapeutic drugs, using nanoparticles, with selective destruction of cancerous cells would minimize the toxicity on healthy tissues. Also, the use of nanomaterials as contrast agent could improve sensitivity and specificity of diagnosis. The purpose of this review is to highlight the recent achievements of cancer research by use of nanomaterials, in the idea of finding the ideal composite, capable to simultaneous diagnostic and treat cancer.
结直肠癌是一个主要的公共卫生问题，是男性中第三常见的癌症，女性中第二常见的癌症。它是癌症死亡的主要原因之一。纳米医学是一个新兴的研究领域，其许多方面都与癌症研究有关。化疗在结直肠癌的治疗中具有重要的作用，但不幸的是，由于无法进行选择性分布、多药耐药性和不良反应，其作用受到限制。近年来，关于纳米技术的研究旨在解决上述问题。使用纳米颗粒靶向和局部递送化疗药物，选择性地破坏癌细胞，将最大限度地减少对健康组织的毒性。此外，纳米材料作为对比剂的使用可以提高诊断的敏感性和特异性。本文的目的是强调使用纳米材料进行癌症研究的最新成果，以期找到一种理想的复合材料，能够同时进行癌症诊断和治疗。
