唾液腺中的水通道蛋白：从基础研究到临床应用

Delporte Christine, Bryla Angélic, Perret Jason

Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, 808 Route de Lennik, Blg G/E CP 611, Brussels B-1070, Belgium.

Int J Mol Sci. 2016 Jan 27;17(2):166. doi: 10.3390/ijms17020166.

Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and is pointing out possible difference between major salivary glands, i.e., parotid, submandibular and sublingual glands.

唾液腺参与唾液分泌，以确保口腔健康。水通道蛋白在唾液腺中表达，并在唾液分泌中起主要作用。本综述将概述唾液腺的形态学以及唾液分泌的生理学，并重点关注水通道蛋白在生理和病理生理条件下的表达、亚细胞定位和作用，以及涉及水通道蛋白的临床应用。本综述着重介绍了水通道蛋白在人类、大鼠和小鼠（这些研究最多的物种）中的表达和定位，并指出主要唾液腺（即腮腺、颌下腺和舌下腺）之间可能存在的差异。