Honma Y, Kasukabe T, Okabe J, Hozumi M
Gan. 1977 Apr;68(2):241-6.
Mouse myeloid leukemia cells were induced by some corticoid hormones to migrate in agar, phagocytize, and change into forms which were morphologically similar to macrophages and granulocytes. Inducing ability of corticoids was correlated with glucocorticoid activity, not mineralocorticoid activity. Other steroids were ineffective to induce differentiation of myeloid leukemia cells. Glucocorticoid-resistant cells, which could not differentiate even in a high concentrations of dexamethasone, were selected from steroid-sensitive cells by stepwise increase in concentrations of dexamethasone in culture medium.
一些皮质激素可诱导小鼠髓性白血病细胞在琼脂中迁移、吞噬，并转变为形态上类似于巨噬细胞和粒细胞的形态。皮质激素的诱导能力与糖皮质激素活性相关，而非盐皮质激素活性。其他类固醇对诱导髓性白血病细胞分化无效。通过在培养基中逐步增加地塞米松浓度，从类固醇敏感细胞中筛选出即使在高浓度地塞米松中也不能分化的糖皮质激素抗性细胞。
