循环纤维细胞在心脏纤维化中的作用。
Role of Circulating Fibrocytes in Cardiac Fibrosis.
作者信息
Lin Rong-Jie, Su Zi-Zhuo, Liang Shu-Min, Chen Yu-Yang, Shu Xiao-Rong, Nie Ru-Qiong, Wang Jing-Feng, Xie Shuang-Lun
机构信息
Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, Guangdong 510120, China.
出版信息
Chin Med J (Engl). 2016 Feb 5;129(3):326-31. doi: 10.4103/0366-6999.174503.
OBJECTIVE
It is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis.
DATA SOURCES
This review is based on the data from 1994 to present obtained from PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ".
STUDY SELECTION
Articles and critical reviews, which are related to circulating fibrocytes and cardiac fibrosis, were selected.
RESULTS
Circulating fibrocytes, which are derived from hematopoietic stem cells, represent a subset of peripheral blood mononuclear cells exhibiting mixed morphological and molecular characteristics of hematopoietic and mesenchymal cells (CD34+/CD45+/collagen I+). They can produce extracellular matrix and many cytokines. It is shown that circulating fibrocytes participate in many fibrotic diseases, including cardiac fibrosis. Evidence accumulated in recent years shows that aging individuals and patients with hypertension, heart failure, coronary heart disease, and atrial fibrillation have more circulating fibrocytes in peripheral blood and/or heart tissue, and this elevation of circulating fibrocytes is correlated with the degree of fibrosis in the hearts.
CONCLUSIONS
Circulating fibrocytes are effector cells in cardiac fibrosis.
目的
研究表明，心脏纤维化患者/动物体内循环纤维细胞水平升高，本综述旨在介绍循环纤维细胞及其在心脏纤维化中的作用。
数据来源
本综述基于1994年至今从PubMed获取的数据。检索词为“循环纤维细胞”和“心脏纤维化”。
研究选择
选取与循环纤维细胞和心脏纤维化相关的文章及综述。
结果
循环纤维细胞来源于造血干细胞，是外周血单个核细胞的一个亚群，具有造血细胞和间充质细胞混合的形态和分子特征（CD34+/CD45+/I型胶原+）。它们可产生细胞外基质和多种细胞因子。研究表明，循环纤维细胞参与包括心脏纤维化在内的多种纤维化疾病。近年来积累的证据显示，老年人以及高血压、心力衰竭、冠心病和心房颤动患者外周血和/或心脏组织中的循环纤维细胞更多，且循环纤维细胞的这种升高与心脏纤维化程度相关。
结论
循环纤维细胞是心脏纤维化中的效应细胞。
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