Voigt R, Schröder S, Bierwisch I, Michels W
Klinik für Frauenheilkunde und Geburtshilfe, Universität Jena/DDR.
Z Geburtshilfe Perinatol. 1989 Sep-Oct;193(5):230-2.
Examining serum level values and urinary concentrations taken from nonpregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the third trimenon, the pharmacokinetic dates after single application of 1 g cefotaxime have been evaluated. We used a computer program based on the two-compartment model. It is shown that during pregnancy complicated by UTI the elimination half-life will be prolonged, the distribution volumes and clearance values will be increased. The results discussed with the dates given by literature allow us to state that it is not necessary to change dosage and application interval of cefotaxime during pregnancy.
通过检测非妊娠对照人群以及妊娠晚期患有尿路感染（UTI）的孕妇的血清水平值和尿液浓度，对单次应用1g头孢噻肟后的药代动力学数据进行了评估。我们使用了基于二室模型的计算机程序。结果表明，在并发UTI的妊娠期，消除半衰期会延长，分布容积和清除率值会增加。将这些结果与文献给出的数据进行讨论后，我们可以得出结论，妊娠期应用头孢噻肟时无需改变剂量和用药间隔。
