Voigt R, Patsch R, Schröder S, Peiker G, Brandstädt A
Z Geburtshilfe Perinatol. 1985 Mar-Apr;189(2):88-90.
Examining blood level values and urinary concentrations taken from pregnant and nonpregnant women, the pharmacokinetic dates of azlocillin have been evaluated. We used a computer program based on the two-compartment model. The evaluation of azlocillin concentrations in serum and urine has been realized with the two following methods: polarography and agar diffusion test. We found nearly equal values of serum concentrations when using both methods. There are no statistical differences between pharmacokinetic dates of pregnant and nonpregnant women. Therefore we state: It is not necessary to change the dosage and the application interval of azlocillin during pregnancy.
通过检测孕妇和非孕妇的血药浓度值及尿药浓度，对阿洛西林的药代动力学数据进行了评估。我们使用了基于二室模型的计算机程序。采用以下两种方法对血清和尿液中的阿洛西林浓度进行了评估：极谱法和琼脂扩散试验。使用这两种方法时，我们发现血清浓度值几乎相等。孕妇和非孕妇的药代动力学数据之间无统计学差异。因此我们声明：孕期无需改变阿洛西林的剂量和用药间隔。
