酵母产生的褪黑素及其他色氨酸代谢产物：对心血管疾病和神经退行性疾病的影响
Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases.
作者信息
Hornedo-Ortega Ruth, Cerezo Ana B, Troncoso Ana M, Garcia-Parrilla M Carmen, Mas Albert
机构信息
Facultad de Farmacia, Universidad de Sevilla Sevilla, Spain.
Facultad de Enología, Universitat Rovira i Virgili Tarragona, Spain.
出版信息
Front Microbiol. 2016 Jan 19;6:1565. doi: 10.3389/fmicb.2015.01565. eCollection 2015.
Abstract
Yeast metabolism produces compounds derived from tryptophan, which are found in fermented beverages, such as wine and beer. In particular, melatonin and serotonin, may be relevant due to their bioactivity in humans. Indeed, the former is a neurohormone related to circadian rhythms, which also has a putative protective effect against degenerative diseases. Moreover, serotonin is a neurotransmitter itself, in addition to being a precursor of melatonin synthesis. This paper summarizes data reported on fermented beverages, to evaluate dietary intake. Additionally, the article reviews observed effects of yeast amino acid metabolites on the prevention of neurodegenerative diseases (Alzheimer's and Parkinson's) and angiogenesis, focusing on evidence of the molecular mechanism involved and identification of molecular targets.
摘要
酵母代谢产生源于色氨酸的化合物，这些化合物存在于葡萄酒和啤酒等发酵饮料中。特别是褪黑素和血清素，因其对人类的生物活性而可能具有相关性。事实上，前者是一种与昼夜节律相关的神经激素，对退行性疾病也有假定的保护作用。此外，血清素本身就是一种神经递质，同时也是褪黑素合成的前体。本文总结了关于发酵饮料的报道数据，以评估膳食摄入量。此外，本文还综述了酵母氨基酸代谢产物对预防神经退行性疾病（阿尔茨海默病和帕金森病）和血管生成的观察效果，重点关注所涉及的分子机制证据和分子靶点的鉴定。
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