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[重组人α干扰素(利分能)对小鼠巨噬细胞功能活性的影响]

[Effect of recombinant human alpha-interferon (reaferon) on macrophage functional activity in mice].

作者信息

Vasilenko R N, Denisov L A, Galaktionov V G

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1989 Jul(7):100-4.

PMID:2683517
Abstract

The influence of human recombinant alpha 2-interferon (reaferon) on the parameters of the phagocytic activity of mouse peritoneal macrophages (migration, spreading, adhesion and absorption of corpuscular antigen) has been studied. Reaferon in doses of 5-5 X 10(2) I. U./ml has been found to produce a stimulating effect on all parameters under study. The data obtained in this study suggest that a stimulating effect on the functional activity of macrophages is the same for recombinant (alpha 2) interferon and natural alpha-interferon.

摘要

研究了人重组α2干扰素(利扰素)对小鼠腹腔巨噬细胞吞噬活性参数(迁移、铺展、黏附及颗粒性抗原吸收)的影响。已发现剂量为5 - 5×10²国际单位/毫升的利扰素对所研究的所有参数均产生刺激作用。本研究获得的数据表明,重组(α2)干扰素和天然α干扰素对巨噬细胞功能活性的刺激作用相同。

相似文献

1
[Effect of recombinant human alpha-interferon (reaferon) on macrophage functional activity in mice].[重组人α干扰素(利分能)对小鼠巨噬细胞功能活性的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1989 Jul(7):100-4.
2
[The immunoregulatory properties of reaferon].[重组干扰素的免疫调节特性]
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Inability of recombinant interferon-gamma to activate the antibacterial activity of mouse peritoneal macrophages against Listeria monocytogenes and Salmonella typhimurium.重组干扰素-γ无法激活小鼠腹腔巨噬细胞对单核细胞增生李斯特菌和鼠伤寒沙门氏菌的抗菌活性。
J Immunol. 1987 Sep 1;139(5):1673-8.
4
[Interferon enhances the bactericidal activity of peritoneal exudate macrophages against Salmonella typhimurium in mice].
Zh Mikrobiol Epidemiol Immunobiol. 1987 Aug(8):76-9.
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[Activation of phagocytosis by preparations of human alpha and gamma interferons].[人α和γ干扰素制剂对吞噬作用的激活]
Vopr Virusol. 1988 Mar-Apr;33(2):181-4.
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Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.干扰素α和β对人巨噬细胞激活的激动剂和拮抗剂作用。两类干扰素γ受体以及干扰素α或β对高亲和力位点的阻断。
J Exp Med. 1988 Mar 1;167(3):1171-85. doi: 10.1084/jem.167.3.1171.
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[The action of interferon and reaferon on the functional activity of human thrombocytes].[干扰素和瑞夫龙对人血小板功能活性的作用]
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[The effect of alpha/beta and gamma interferon preparations on the functional activity of macrophages in experimental staphylococcal infections].[α/β干扰素和γ干扰素制剂对实验性葡萄球菌感染中巨噬细胞功能活性的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1989 Apr(4):57-60.
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[The results of preclinical trials of the Soviet recombinant preparation of human interferon alpha-2 (reaferon)].[苏联重组人α-2干扰素制剂(利夫罗芬)的临床前试验结果]
Zh Mikrobiol Epidemiol Immunobiol. 1990 Jun(6):93-7.
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