Kent B A, Hvoslef-Eide M, Saksida L M, Bussey T J
Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada.
Department of Psychology, University of Cambridge, Cambridge, UK.
Neurobiol Learn Mem. 2016 Mar;129:99-106. doi: 10.1016/j.nlm.2016.01.006. Epub 2016 Feb 1.
Pattern separation (PS) has been defined as a process of reducing overlap between similar input patterns to minimize interference amongst stored representations. The present article describes this putative PS process from the "representational-hierarchical" perspective (R-H), which uses a hierarchical continuum instead of a cognitive modular processing framework to describe the organization of the ventral visual perirhinal-hippocampal processing stream. Instead of trying to map psychological constructs onto anatomical modules in the brain, the R-H model suggests that the function of brain regions depends upon what representations they contain. We begin by discussing a main principle of the R-H framework, the resolution of "ambiguity" of lower level representations via the formation of unique conjunctive representations in higher level areas, and how this process is remarkably similar to definitions of PS. Work from several species and experimental approaches suggest that this principle of resolution of ambiguity via conjunctive representations has considerable explanatory power, leads to wide possibilities for experimentation, and also supports some perhaps surprising conclusions.
模式分离（PS）被定义为一个减少相似输入模式之间重叠的过程，以最小化存储表征之间的干扰。本文从“表征层次”视角（R-H）描述了这种假定的PS过程，该视角使用层次连续体而非认知模块化处理框架来描述腹侧视觉嗅周-海马处理流的组织。R-H模型并非试图将心理结构映射到大脑中的解剖模块上，而是表明脑区的功能取决于它们所包含的表征。我们首先讨论R-H框架的一个主要原则，即通过在更高层次区域形成独特的联合表征来解决较低层次表征的“模糊性”，以及这个过程如何与PS的定义非常相似。来自多个物种和实验方法的研究表明，通过联合表征解决模糊性的这一原则具有相当大的解释力，为实验带来了广泛的可能性，并且还支持了一些可能令人惊讶得出结论。
