Waschke Leonhard, Kamp Fabian, van den Elzen Evi, Krishna Suresh, Lindenberger Ulman, Rutishauser Ueli, Garrett Douglas D
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Nat Commun. 2025 Jan 2;16(1):236. doi: 10.1038/s41467-024-55406-4.
During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.
在记忆形成过程中，海马体被认为代表着刺激的内容，但其具体方式尚不清楚。通过计算建模和人类单神经元记录，我们发现海马体放电变异性越精确地追踪每个单独刺激的复合特征，这些刺激随后被记住的效果就越好。我们提出，瞬间放电变异性可能为海马体如何从我们感官世界的基本要素构建记忆提供一个新的窗口。
