Tsuchiyama Kenichiro, Watabe Akiko, Sadayasu Anna, Onodera Nobue, Kimura Yutaka, Aiba Setsuya
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Dermatology. 2016;232(2):237-41. doi: 10.1159/000442666. Epub 2016 Feb 3.
Minigrafts using a 1-mm biopsy punch (1-mm minigrafts) are being increasingly used to treat vitiligo. However, there have been few reports of the use of 1-mm minigrafts in pediatric patients.
To examine the effectiveness of combination therapy with 1-mm minigrafts and phototherapy in children with segmental vitiligo.
Minigrafts were placed in 13 patients aged ≤16 years with segmental vitiligo. Following surgery, 11 patients underwent irradiation with excimer laser light and 2 with narrow-band ultraviolet B light.
A mean repigmentation of 81.6% was obtained. A particularly high mean repigmentation of 87.9% was seen in patients aged ≤12 years, indicating greater efficacy in these patients than in patients aged ≥13 years (mean, 67.5%). Although a transient cobblestone appearance occurred as an adverse effect, it improved over time.
Combined treatment of segmental vitiligo with 1-mm minigrafts and phototherapy can be performed safely and is highly effective in young patients.
使用1毫米活检打孔器的微小皮片移植（1毫米微小皮片移植）越来越多地用于治疗白癜风。然而，关于在儿科患者中使用1毫米微小皮片移植的报道很少。
研究1毫米微小皮片移植联合光疗治疗节段性白癜风患儿的有效性。
对13例年龄≤16岁的节段性白癜风患者进行微小皮片移植。术后，11例患者接受准分子激光照射，2例接受窄谱中波紫外线照射。
平均色素恢复率为81.6%。年龄≤12岁的患者平均色素恢复率特别高，为87.9%，表明这些患者比年龄≥13岁的患者（平均为67.5%）疗效更好。尽管出现了短暂的鹅卵石样外观作为不良反应，但随着时间的推移有所改善。
1毫米微小皮片移植联合光疗治疗节段性白癜风对年轻患者安全有效。
