Wang Yanling, Dou Yugui, Zhu Xiaonan, Zheng Jing
Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China; Email:
Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Oct;36(10):1095-8.
To understand the iodine nutrition and thyroid function of different population in urban and rural areas of Gansu province and provide evidence for iodine supplementation.
A cross-sectional survey was performed in urban and rural children, adults, pregnant women and breastfeeding women in Wuwei from April 2009 to January 2010. Urine and fasting blood samples were collected from the subjects. Urine iodine content was measured with arsenic cerium catalytic spectrophatometry. The thyroid-stimulating hormone (TSH) , free thyroid hormone (FT4) and three free triiodothyronine (FT3) were detected by using direct chemiluminescence immunoassy. Non parametric test was used to compare the urinary iodine and TSH group. t test was used to compare FT4, FT3. χ² test was used to compare the rate.
The medians of urinary iodine level (µg/L) were 358.6, 189.0, 255.4 and 239.5 in urban children, adults, pregnant women and breastfeeding women and 387.6, 258.5, 172.8 and 215.3 in rural children, adults, pregnant women and breastfeeding women respectively. The median of urinary iodine of urban adults was significantly lower than that in rural adults (Z=-4.020, P=0.000) and the medians of urinary iodine level of urban pregnant women was higher than that in rural pregnant women (Z=1.424, P=0.035). The mean value of FT3 in rural pregnant women and breastfeeding women were higher than that in urban groups (t=-3.933, P=0.000; t=-2.259, P=0.026). The mean value of FT4 in urban adults was higher than that in rural adults (t=3.539, P=0.001). The positive rate of TGAb and TMAb in rural pregnant women and breastfeeding women were 43.6%, 56.4% and 33.3%, 35.6%, respectively, which were higher than those in urban groups. Subclinical hypothyroidism in all thyroid function disorders was common in all the groups. No statistical significant difference in all thyroid function disorders were found in different population.
The iodine nutrition were in good status in both urban population and rural population, the children's iodine nutrition was surplus. Statistical differences existed in iodine nutrition status or thyroid hormone level between urban and rural adults, pregnant women and breastfeeding women.
了解甘肃省城乡不同人群的碘营养状况及甲状腺功能，为碘补充提供依据。
于2009年4月至2010年1月在武威市城乡儿童、成年人、孕妇及哺乳期妇女中进行横断面调查。采集研究对象的尿液及空腹血样本。采用砷铈催化分光光度法测定尿碘含量。采用直接化学发光免疫分析法检测促甲状腺激素（TSH）、游离甲状腺激素（FT4）及游离三碘甲状腺原氨酸（FT3）。采用非参数检验比较尿碘及TSH组间差异，采用t检验比较FT4、FT3，采用χ²检验比较率。
城市儿童、成年人、孕妇及哺乳期妇女尿碘水平（μg/L）中位数分别为358.6、189.0、255.4及239.5，农村儿童、成年人、孕妇及哺乳期妇女分别为387.6、258.5、172.8及215.3。城市成年人尿碘中位数显著低于农村成年人（Z=-4.020，P=0.000），城市孕妇尿碘中位数高于农村孕妇（Z=1.424，P=0.035）。农村孕妇及哺乳期妇女FT3均值高于城市组（t=-3.933，P=0.000；t=-2.259，P=0.026）。城市成年人FT4均值高于农村成年人（t=3.539，P=0.001）。农村孕妇及哺乳期妇女甲状腺球蛋白抗体（TGAb）及甲状腺微粒体抗体（TMAb）阳性率分别为43.6%、56.4%及33.3%、35.6%，高于城市组。亚临床甲状腺功能减退在所有甲状腺功能异常中在各组均较为常见。不同人群在所有甲状腺功能异常方面未发现统计学显著差异。
城乡人群碘营养状况良好，儿童碘营养过剩。城乡成年人、孕妇及哺乳期妇女在碘营养状况及甲状腺激素水平方面存在统计学差异。
