Kaewpitoon Soraya J, Loyd Ryan A, Rujirakul Ratana, Panpimanmas Sukij, Matrakool Likit, Tongtawee Taweesak, Kootanavanichpong Nusorn, Pengsaa Prasit, Kompor Ponthip, Chavengkun Wasugree, Kujapun Jirawoot, Norkaew Jun, Ponphimai Sukanya, Padchasuwan Natnapa, Polsripradist Poowadol, Eksanti Thawatchai, Phatisena Tanida, Kaewpitoon Natthawut
School of Family Medicine and Community Medicine, Suranaree University of Technology, Thailand E-mail :
Asian Pac J Cancer Prev. 2016;17(1):37-44. doi: 10.7314/apjcp.2016.17.1.37.
Several infectious agents are considered to be causes of cancer in human, mainly hepatitis B and C viruses, high-risk human pailloma viruses, Helicobacter pylori, Clonorchis sinensis, and Opisthorchis viverrini. Here we described the evident research and the association between Helicobacter spp. and biliary tract cancer particularly cholangiocarcinoma (CCA). Global epidemiological studies have suggested that Helicobacter spp. are possible risk factors for biliary tract diseases. Molecular studies support a linkage of Helicobacter spp. with CCA development. H. pylori, H. bilis, and H. hepaticus, are found in CCA, but the most common species are H. pylori and H. bilis. The type of CCA are associated with Helicobacter spp. include extrahepatic CCA, and common bile duct cancer. Up to the present, however, the results from different regions, materials and methods, sub-sites of cancer, and controls have not been consistent, thus introducing heterogeneity. Therefore, a comparison between co-Helicobacter spp.-CCA in the countries with low and high incident of CCA is required to settle the question. Furthermore, clarifying variation in the role of Helicobacter species in this CCA, including pathogenesis of CCA through enhanced biliary cell inflammation and proliferation, is necessary.
几种感染因子被认为是人类癌症的病因，主要包括乙型和丙型肝炎病毒、高危人乳头瘤病毒、幽门螺杆菌、华支睾吸虫和麝猫后睾吸虫。在此，我们描述了关于幽门螺杆菌属与胆道癌尤其是胆管癌（CCA）之间的显著研究及关联。全球流行病学研究表明，幽门螺杆菌属可能是胆道疾病的风险因素。分子研究支持幽门螺杆菌属与CCA发生之间存在联系。在CCA中发现了幽门螺杆菌、胆汁螺杆菌和肝螺杆菌，但最常见的种类是幽门螺杆菌和胆汁螺杆菌。与幽门螺杆菌属相关的CCA类型包括肝外CCA和胆总管癌。然而，截至目前，来自不同地区研究的结果、材料和方法、癌症亚部位以及对照并不一致，从而导致了异质性。因此，需要比较CCA发病率低和高的国家中幽门螺杆菌属与CCA的关系，以解决这一问题。此外，有必要阐明幽门螺杆菌属在这种CCA中的作用差异，包括通过增强胆管细胞炎症和增殖导致CCA发病的机制。
