Albuquerque Andreia, Cardoso Hélder, Marques Margarida, Rodrigues Susana, Vilas-Boas Filipe, Lopes Susana, Dias Cláudia Camila, Macedo Guilherme
Gastroenterology, Centro Hospitalar São João, Portugal.
Gastroenterology, Centro Hospitalar S. João, Portugal.
Rev Esp Enferm Dig. 2016 Feb;108(2):65-70. doi: 10.17235/reed.2015.3957/2015.
Patency capsule was developed to avoid small bowel video capsule endoscopy retention, namely in patients with Crohn's disease.
To evaluate the predictive factors of small bowel patency in Crohn's disease patients.
Retrospective analysis including 151 Crohn's disease patients submitted to patency capsule (Agile® Patency Capsule) from 2011 to 2012. Patients that excreted the intact patency capsule were classified as having a patent small bowel (without patency capsule retention), other patients were considered to have negative patency of the small bowel (patency capsule retention).
Patients had a mean age of 41±14 years, 54% were female and 25% had been previously submitted to surgery. Stricturing disease was seen in 20% of cases and penetrating disease in 16% of cases. Left-sided colonic lesions and ileal strictures were observed at colonoscopy in 13% and 9% of patients, respectively. In our sample, 28% of patients had negative patency of the small bowel (patency capsule retention). In multivariate analysis, independent factors that were associated with negative patency of the small bowel in Crohn's disease patients were stricturing (OR 10.16, p < 0.001) and penetrating phenotypes (OR 11.73, p = 0.001), left-sided colonic lesions (OR 3.77, p = 0.038), ileal stricture (OR 9.76, p = 0.003); previous intestinal surgery was found to be protective (OR 0.16, p = 0.006).
Stricturing or penetrating disease, ileal strictures, no previous surgery and left-sided colonic lesions were the factors associated with negative small bowel patency in Crohn's disease patients.
通畅胶囊旨在避免小肠视频胶囊内镜滞留，即用于克罗恩病患者。
评估克罗恩病患者小肠通畅的预测因素。
回顾性分析2011年至2012年接受通畅胶囊（Agile®通畅胶囊）检查的151例克罗恩病患者。排出完整通畅胶囊的患者被分类为小肠通畅（无通畅胶囊滞留），其他患者被认为小肠通畅阴性（通畅胶囊滞留）。
患者平均年龄为41±14岁，54%为女性，25%曾接受过手术。20%的病例出现狭窄性疾病，16%的病例出现穿透性疾病。结肠镜检查时，分别有13%和9%的患者观察到左侧结肠病变和回肠狭窄。在我们的样本中，28%的患者小肠通畅阴性（通畅胶囊滞留）。多因素分析显示，与克罗恩病患者小肠通畅阴性相关的独立因素为狭窄（比值比10.16，p<0.001）、穿透性表型（比值比11.73，p = 0.001）、左侧结肠病变（比值比3.77，p = 0.038）、回肠狭窄（比值比9.76，p = 0.003）；既往肠道手术具有保护作用（比值比0.16，p = 0.006）。
狭窄或穿透性疾病、回肠狭窄、既往未手术以及左侧结肠病变是与克罗恩病患者小肠通畅阴性相关的因素。
