肠道微生物色氨酸代谢产物可抑制类固醇激素合成细胞色素P450 11A1。 - Suppr

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超能文献

Products of gut-microbial tryptophan metabolism inhibit the steroid hormone-synthesizing cytochrome P450 11A1.

作者信息

Mosa A, Gerber A, Neunzig J, Bernhardt Rita

机构信息

Institute of Biochemistry, Campus B 2.2, Saarland University, 66123, Saarbrücken, Germany.

出版信息

Endocrine. 2016 Aug;53(2):610-4. doi: 10.1007/s12020-016-0874-0. Epub 2016 Feb 2.

DOI:10.1007/s12020-016-0874-0

PMID:26839092

Abstract

摘要

相似文献

Products of gut-microbial tryptophan metabolism inhibit the steroid hormone-synthesizing cytochrome P450 11A1.肠道微生物色氨酸代谢产物可抑制类固醇激素合成细胞色素P450 11A1。

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Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1).推测的F-G环参与了细胞色素P450侧链裂解酶（P450 11A1）与膜的结合。

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Endocrinology. 1988 May;122(5):1948-57. doi: 10.1210/endo-122-5-1948.

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本文引用的文献

Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration?吲哚：一种信号分子还是仅仅是一种在高浓度时会改变细菌生理机能的代谢副产物？

J Microbiol. 2015 Jul;53(7):421-8. doi: 10.1007/s12275-015-5273-3. Epub 2015 Jun 27.

2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation.CYP11A1的2β-和16β-羟化酶活性以及雌激素对孕烯醇酮生成的直接刺激作用。

J Steroid Biochem Mol Biol. 2015 Jun;150:1-10. doi: 10.1016/j.jsbmb.2015.02.014. Epub 2015 Mar 3.

Intestinal steroidogenesis.

Steroids. 2015 Nov;103:64-71. doi: 10.1016/j.steroids.2014.12.022. Epub 2015 Jan 2.

Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis.肠道类固醇生成控制结肠中 PPARγ 的表达，并在溃疡性结肠炎期间受损。

Gut. 2015 Jun;64(6):901-10. doi: 10.1136/gutjnl-2014-307618. Epub 2014 Jul 22.

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations.细胞色素 P450 作为有前途的生物技术应用的催化剂：机遇与限制。

Appl Microbiol Biotechnol. 2014;98(14):6185-203. doi: 10.1007/s00253-014-5767-7. Epub 2014 May 22.

Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones.硫酸脱氢表雄酮（DHEAS）刺激类固醇激素生物合成的第一步。

PLoS One. 2014 Feb 21;9(2):e89727. doi: 10.1371/journal.pone.0089727. eCollection 2014.

Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.肿瘤坏死因子抑制 NR5A2 活性和肠道糖皮质激素合成，以维持慢性结肠炎。

Sci Signal. 2014 Feb 25;7(314):ra20. doi: 10.1126/scisignal.2004786.

Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan.色氨酸酶 TnaA 在大肠杆菌中产生吲哚的量取决于外源性色氨酸的量。

Microbiology (Reading). 2013 Feb;159(Pt 2):402-410. doi: 10.1099/mic.0.064139-0.

Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions.新型通用电子转移系统在基于细胞色素 P450 的大肠杆菌全细胞生物转化中的应用。

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Biochim Biophys Acta. 2011 Aug;1812(8):947-55. doi: 10.1016/j.bbadis.2010.12.010. Epub 2010 Dec 29.

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