Jaroszewski Jerzy, Mamun Niles, Czaja Krzysztof
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland.
Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Antibiotics (Basel). 2023 Sep 12;12(9):1438. doi: 10.3390/antibiotics12091438.
The escalating misuse of antibiotics, particularly broad-spectrum antibiotics, has emerged as a pivotal driver of drug resistance. Among these agents, tetracyclines are widely prescribed for bacterial infections, but their indiscriminate use can profoundly alter the gut microbiome, potentially compromising both their effectiveness and safety. This review delves into the intricate and dynamic interplay between tetracyclines and the gut microbiome, shedding light on their reciprocal influence. By exploring the effects of tetracyclines on the gut microbiome and the impact of gut microbiota on tetracycline therapy, we seek to gain deeper insights into this complex relationship, ultimately guiding strategies for preserving antibiotic efficacy and mitigating resistance development.
抗生素的滥用情况日益严重，尤其是广谱抗生素，已成为耐药性的关键驱动因素。在这些药物中，四环素被广泛用于治疗细菌感染，但其滥用会深刻改变肠道微生物群，可能影响其有效性和安全性。本综述深入探讨了四环素与肠道微生物群之间复杂而动态的相互作用，揭示了它们的相互影响。通过研究四环素对肠道微生物群的影响以及肠道微生物群对四环素治疗的影响，我们试图更深入地了解这种复杂关系，最终指导保护抗生素疗效和减缓耐药性发展的策略。
