Haack Timm, Abdelilah-Seyfried Salim
Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Straße 1, Hannover D-30625, Germany.
Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Straße 1, Hannover D-30625, Germany Institute of Biochemistry and Biology, Potsdam University, Karl-Liebknecht-Straße 24-25, Potsdam D-14476, Germany
Development. 2016 Feb 1;143(3):373-86. doi: 10.1242/dev.131425.
Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flow-responsive endocardial signalling can result in pathophysiological changes.
心内膜细胞是衬于心管内部的心脏内皮细胞。从历史上看，它们对心脏发育的贡献主要是从形态学角度来考虑的。然而，最近的研究已开始明确心内膜的新的指导作用，即作为血流诱导的生物物理力的传感器和信号转导器，以及作为参与心肌细胞形态发生、再生和重编程的血管分泌信号中心。在本综述中，我们讨论了心内膜如何发育、心内膜-心肌相互作用如何影响发育中的胚胎心脏，以及血流反应性心内膜信号的失调如何导致病理生理变化。
