Andrés-Delgado Laura, Mercader Nadia
Development of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Development of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029 Madrid, Spain; Institute of Anatomy, University of Bern, Bern, Switzerland.
Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1707-16. doi: 10.1016/j.bbamcr.2016.03.004. Epub 2016 Mar 4.
Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
机械转导是指将机械力转化为生化或电信号，从而启动细胞和组织的结构与功能重塑。心脏是一个动态器官，其形态在发育和疾病过程中会发生显著变化。这就要求心肌细胞具备机械耐久性，并能够在不同时间尺度上对各种环境信号（包括心脏压力负荷以及电和血流动力学力）做出协调反应。在生理生长过程中，心肌细胞、心内膜和心外膜细胞必须对这些机械力进行适应性重塑。在此，我们回顾了在理解机械力如何影响心脏发育方面的一些最新进展，重点关注流体流动作用力。本文是由马库斯·绍布和休斯·阿布里尔编辑的名为《心肌细胞生物学：心脏发育与环境信号的整合》特刊的一部分。
