Wong Darren, Fries Bettina
Department of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY, USA.
IDCases. 2014 Sep 6;1(4):66-7. doi: 10.1016/j.idcr.2014.08.003. eCollection 2014.
Anti-N-methyl-d-aspartate receptor encephalitis has become an increasingly recognized etiology of acute psychosis in young patients. The diverse constellation of symptoms allows for misdiagnosis as an infectious, psychological, or toxicological entity resulting in delays in treatment with increasing morbidity. We describe a case of anti-NMDAR encephalitis that was a particular challenge to diagnose. Practitioners should maintain a high index of suspicion for anti-NMDAR and related neuroautoimmune syndromes, especially in young patients that present with acute mental status decline or dyskinesia.
抗N-甲基-D-天冬氨酸受体脑炎已日益被认为是年轻患者急性精神病的病因。其多样的症状群可能导致误诊为感染性、心理性或中毒性疾病,从而延误治疗并增加发病率。我们描述了一例诊断颇具挑战的抗NMDAR脑炎病例。从业者应高度怀疑抗NMDAR及相关神经自身免疫综合征,尤其是对于出现急性精神状态衰退或运动障碍的年轻患者。