• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于离子液体中多组分策略的二氮杂七环笼状体系立体选择性合成的可持续方法。

A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid.

作者信息

Suresh Kumar Raju, Almansour Abdulrahman I, Arumugam Natarajan, Altaf Mohammad, Menéndez José Carlos, Kumar Raju Ranjith, Osman Hasnah

机构信息

Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia.

Central Laboratory, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia.

出版信息

Molecules. 2016 Jan 29;21(2):165. doi: 10.3390/molecules21020165.

DOI:10.3390/molecules21020165
PMID:26840282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6273701/
Abstract

The microwave-assisted three-component reactions of 3,5-bis(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones, acenaphthenequinone and cyclic α-amino acids in an ionic liquid, 1-butyl-3-methylimidazolium bromide, occurred through a domino sequence affording structurally intriguing diazaheptacyclic cage-like compounds in excellent yields.

摘要

在离子液体1-丁基-3-甲基咪唑溴盐中，3,5-双（E）-芳基亚甲基]四氢-4（1H）-吡啶酮、苊醌和环状α-氨基酸的微波辅助三组分反应通过多米诺序列进行，以优异的产率得到结构有趣的二氮杂七环笼状化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/9ad6daa7f288/molecules-21-00165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/abd614be9a0f/molecules-21-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/a971f73159f4/molecules-21-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/f6f968d37ad7/molecules-21-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/9324b1877cee/molecules-21-00165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/081771d9da24/molecules-21-00165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/9ad6daa7f288/molecules-21-00165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/abd614be9a0f/molecules-21-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/a971f73159f4/molecules-21-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/f6f968d37ad7/molecules-21-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/9324b1877cee/molecules-21-00165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/081771d9da24/molecules-21-00165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8d2/6273701/9ad6daa7f288/molecules-21-00165-g006.jpg

相似文献

1
A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid.基于离子液体中多组分策略的二氮杂七环笼状体系立体选择性合成的可持续方法。
Molecules. 2016 Jan 29;21(2):165. doi: 10.3390/molecules21020165.
2
[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole-Pyrrolidine Heterocyclic Hybrids.[Bmim]Br 促进的一锅法三组分级联反应协议，用于构建螺环吲哚-吡咯烷杂环类混合物。
Molecules. 2020 Oct 18;25(20):4779. doi: 10.3390/molecules25204779.
3
Catalyst-free one-pot four component synthesis of polysubstituted imidazoles in neutral ionic liquid 1-butyl-3-methylimidazolium bromide.在中性离子液体1-丁基-3-甲基咪唑溴化物中无催化剂一锅法四组分合成多取代咪唑。
J Comb Chem. 2010 Nov 8;12(6):844-9. doi: 10.1021/cc100097m. Epub 2010 Sep 9.
4
Microwave-assisted rapid conversion of carbohydrates into 5-hydroxymethylfurfural by ScCl3 in ionic liquids.三氯化钪在离子液体中微波辅助快速将碳水化合物转化为 5-羟甲基糠醛。
Carbohydr Res. 2013 Jun 28;375:68-72. doi: 10.1016/j.carres.2013.04.003. Epub 2013 Apr 11.
5
The Role Ionic Liquid [BMIM][PF] in One-Pot Synthesis of Tetrahydropyran Rings through Tandem Barbier-Prins Reaction.离子液体 [BMIM][PF6] 在通过串联 Barbier-Prins 反应一锅合成四氢吡喃环中的作用。
Molecules. 2019 May 31;24(11):2084. doi: 10.3390/molecules24112084.
6
Microwave-Assisted Syntheses in Recyclable Ionic Liquids: Photoresists Based on Renewable Resources.可循环离子液体中的微波辅助合成：基于可再生资源的光刻胶
ChemSusChem. 2015 Oct 26;8(20):3401-4. doi: 10.1002/cssc.201500847. Epub 2015 Sep 10.
7
Microwave-assisted separation of ionic liquids from aqueous solution of ionic liquids.微波辅助从离子液体水溶液中分离离子液体。
J Chromatogr A. 2010 Dec 3;1217(49):7638-41. doi: 10.1016/j.chroma.2010.10.028. Epub 2010 Oct 11.
8
Application of ionic liquids in the microwave-assisted extraction of proanthocyanidins from Larix gmelini bark.离子液体在微波辅助提取兴安落叶松树皮原花青素中的应用。
Int J Mol Sci. 2012;13(4):5163-5178. doi: 10.3390/ijms13045163. Epub 2012 Apr 24.
9
Microwave-Assisted Resolution of α-Lipoic Acid Catalyzed by an Ionic Liquid Co-Lyophilized Lipase.离子液体共冻干脂肪酶催化微波辅助拆分α-硫辛酸
Molecules. 2015 May 29;20(6):9949-60. doi: 10.3390/molecules20069949.
10
Ultrasound-promoted synthesis of oximes catalyzed by a basic ionic liquid [bmIm]OH.碱性离子液体[bmIm]OH催化超声促进肟的合成。
Ultrason Sonochem. 2009 Mar;16(3):301-3. doi: 10.1016/j.ultsonch.2008.09.003. Epub 2008 Sep 26.

引用本文的文献

1
Design, Synthesis and In Vitro Mechanistic Investigation of Novel Hexacyclic Cage-Like Hybrid Heterocycles.新型六元环笼状杂环混合化合物的设计、合成及体外机制研究。
Molecules. 2019 Oct 23;24(21):3820. doi: 10.3390/molecules24213820.

本文引用的文献

1
An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3']-pyrrolidine and Spiro[oxindole-3,2'-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction.通过离子液体介导的多组分反应，便捷地区域和非对映选择性合成具有嵌入螺[9,10]二氢蒽[9,3']-吡咯烷和螺[氧化吲哚-3,2'-吡咯烷]基序的杂化骨架。
Molecules. 2015 Sep 3;20(9):16142-53. doi: 10.3390/molecules200916142.
2
Regio- and Stereoselective Synthesis of Spiropyrrolizidines and Piperazines through Azomethine Ylide Cycloaddition Reaction.通过甲亚胺叶立德环加成反应实现螺吡咯烷和哌嗪的区域和立体选择性合成。
J Org Chem. 2015 Sep 18;80(18):9064-75. doi: 10.1021/acs.joc.5b01399. Epub 2015 Aug 31.
3
An expedient synthesis, acetylcholinesterase inhibitory activity, and molecular modeling study of highly functionalized hexahydro-1,6-naphthyridines.
高官能化六氢-1,6-萘啶的简便合成、乙酰胆碱酯酶抑制活性及分子模拟研究
Biomed Res Int. 2015;2015:965987. doi: 10.1155/2015/965987. Epub 2015 Jan 29.
4
A facile ionic liquid promoted synthesis, cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines.新型高度官能化螺吡咯烷的简便离子液体促进合成、胆碱酯酶抑制活性及分子模拟研究
Molecules. 2015 Jan 29;20(2):2296-309. doi: 10.3390/molecules20022296.
5
Facile, regio- and diastereoselective synthesis of spiro-pyrrolidine and pyrrolizine derivatives and evaluation of their antiproliferative activities.螺环吡咯烷和吡咯嗪衍生物的简便、区域和非对映选择性合成及其抗增殖活性评估。
Molecules. 2014 Jul 10;19(7):10033-55. doi: 10.3390/molecules190710033.
6
An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors.一项关于藤黄酸注射液治疗晚期恶性肿瘤的开放性、随机、多中心 IIa 期研究。
Chin Med J (Engl). 2013;126(9):1642-6.
7
An expedient synthesis and screening for antiacetylcholinesterase activity of piperidine embedded novel pentacyclic cage compounds.哌啶嵌入新型五环笼状化合物的简便合成及其抗乙酰胆碱酯酶活性筛选
Med Chem. 2014 Mar;10(2):228-36. doi: 10.2174/157340641002140131170054.
8
11-[(E)-2-Fluoro-benzyl-idene]-8-(2-fluoro-phen-yl)-14-hy-droxy-6-thia-3,13-diaza-hepta-cyclo-[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra-cosa-1(22),15(23),16,18,20-pentaen-10-one.11-[(E)-2-氟亚苄基]-8-(2-氟苯基)-14-羟基-6-硫杂-3,13-二氮杂十七环-[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]二十四碳-1(22),15(23),16,18,20-五烯-10-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2094-5. doi: 10.1107/S1600536812025512. Epub 2012 Jun 13.
9
14-Hy-droxy-11-[(E)-4-meth-oxy-benzyl-idene]-8-(4-meth-oxy-phen-yl)-5-thia-3,13-diaza-hepta-cyclo-[13.7.1.1.0.0.0.0]tetra-cosa-1(22),15(23),16,18,20-pentaen-10-one.14-羟基-11-[(E)-4-甲氧基亚苄基]-8-(4-甲氧基苯基)-5-硫杂-3,13-二氮杂十七环-[13.7.1.1.0.0.0.0]二十四碳-1(22),15(23),16,18,20-五烯-10-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o2881-2. doi: 10.1107/S160053681104061X. Epub 2011 Oct 8.
10
Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.新型六环笼状化合物的合成与发现及其作为乙酰胆碱酯酶抑制剂的作用。
Bioorg Med Chem Lett. 2011 Jul 1;21(13):3997-4000. doi: 10.1016/j.bmcl.2011.05.003. Epub 2011 May 8.