Abreu Taciana Cavalcanti de, Lima Rodrigo Pontes de, Souza Veridiana Sales Barbosa de, Campos Júnior Olavio, Albuquerque Amanda Vasconcelos de, Aguiar José Lamartine de Andrade, Andrade Emanuel Sávio de Souza, Vasconcelos Belmiro Cavalcanti do Egito
Universidade de Pernambuco, Recife, PE, Brazil.
Department of Surgery, UFPE, Recife, PE, Brazil.
Acta Cir Bras. 2016 Jan;31(1):53-8. doi: 10.1590/S0102-865020160010000008.
To evaluate the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation.
Thirty Wistar rats were submitted to a one 7-mm-diameter defect and divided equally into three experimental groups, with two different postoperative times of evaluation, 90 and 120 days. Each calvaria defect was filled up with clot (control group), particulated autogenous bone or granulated SCB. Five animals of each group were assessed at 90 and 120 days after surgery. In these two periods, histological and histometric analysis were obtained.
The clot group showed a bone resorption trend while the autogenous bone group a bone repair trend. However in the SCB group, the critical defect filled up only with fibrous connective tissue and presented none bone neoformation.
The sugarcane biopolymer when used in critical size defects was a biocompatible material and proved to be a good material to fill bone cavities, keeping them as uniform areas filled with soft tissue and avoiding the tissue shrinkage.
评估颗粒状（颗粒形）甘蔗渣生物聚合物（SCB）对骨修复的影响，并将其与生物相容性和骨新形成相关联。
30只Wistar大鼠制造一个直径7毫米的缺损，并平均分为三个实验组，有两个不同的术后评估时间，即90天和120天。每个颅骨缺损用血凝块（对照组）、颗粒状自体骨或颗粒状SCB填充。每组五只动物在术后90天和120天进行评估。在这两个时间段，进行组织学和组织计量学分析。
血凝块组显示出骨吸收趋势，而自体骨组显示出骨修复趋势。然而，在SCB组中，临界缺损仅充满纤维结缔组织，未出现骨新形成。
甘蔗生物聚合物用于临界尺寸缺损时是一种生物相容性材料，并且被证明是填充骨腔的良好材料，可使骨腔保持为充满软组织的均匀区域，并避免组织收缩。
