• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

What is the nature of mecamylamine's antagonism of the central effects of nicotine?

作者信息

Martin B R, Onaivi E S, Martin T J

机构信息

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond.

出版信息

Biochem Pharmacol. 1989 Oct 15;38(20):3391-7. doi: 10.1016/0006-2952(89)90106-8.

DOI:10.1016/0006-2952(89)90106-8
PMID:2684166
Abstract
摘要

相似文献

1
What is the nature of mecamylamine's antagonism of the central effects of nicotine?美卡拉明对尼古丁中枢效应的拮抗作用本质是什么?
Biochem Pharmacol. 1989 Oct 15;38(20):3391-7. doi: 10.1016/0006-2952(89)90106-8.
2
Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.
J Pharmacol Exp Ther. 1990 Jul;254(1):45-51.
3
Structural requirements for nicotinic antagonists in the CNS.中枢神经系统中烟碱拮抗剂的结构要求。
NIDA Res Monogr. 1989;95:514-5.
4
Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats.
J Pharmacol Exp Ther. 1991 Aug;258(2):403-9.
5
Neurochemical and behavioral effects of bupropion and mecamylamine in the presence of nicotine.安非他酮和美加明在尼古丁存在情况下的神经化学及行为效应。
Brain Res. 2006 Oct 30;1117(1):18-24. doi: 10.1016/j.brainres.2006.07.110. Epub 2006 Sep 1.
6
Involvement of calcium and L-type channels in nicotine-induced antinociception.
J Pharmacol Exp Ther. 1993 Sep;266(3):1330-8.
7
Inhibition by neosurugatoxin of nicotine-induced antinociception.
Brain Res. 1986 Jun 11;375(2):360-2. doi: 10.1016/0006-8993(86)90758-4.
8
Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion.
J Pharmacol Exp Ther. 1994 Oct;271(1):125-33.
9
Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level.如血浆尼古丁水平的变化所示,美加明预处理会增加随后的尼古丁自我给药量。
Psychopharmacology (Berl). 1987;91(3):391-3. doi: 10.1007/BF00518198.
10
Mecamylamine inhibits nicotine but not capsaicin irritation on the tongue: psychophysical evidence that nicotine and capsaicin activate separate molecular receptors.美加明抑制尼古丁对舌头的刺激,但不抑制辣椒素对舌头的刺激:尼古丁和辣椒素激活不同分子受体的心理物理学证据。
Neurosci Lett. 1998 Jan 9;240(2):65-8. doi: 10.1016/s0304-3940(97)00930-0.

引用本文的文献

1
What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders.我们从伊博加因中获得的启示:α3β4 烟碱型乙酰胆碱受体抑制剂作为物质使用障碍的治疗方法。
J Med Chem. 2023 Jan 12;66(1):107-121. doi: 10.1021/acs.jmedchem.2c01562. Epub 2022 Nov 28.
2
Cholinergic mechanisms in spinal locomotion-potential target for rehabilitation approaches.脊髓运动中的胆碱能机制——康复方法的潜在靶点
Front Neural Circuits. 2014 Nov 6;8:132. doi: 10.3389/fncir.2014.00132. eCollection 2014.
3
Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.
大鼠的内感受性条件反射:使用单一训练剂量或一组 5 种不同剂量尼古丁的效果。
Pharmacol Biochem Behav. 2013 Dec;114-115:82-9. doi: 10.1016/j.pbb.2013.10.025. Epub 2013 Nov 5.
4
Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems.精神分裂症的神经认知内表型:烟碱受体系统的调节作用
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jul 3;52:79-85. doi: 10.1016/j.pnpbp.2013.07.010. Epub 2013 Jul 19.
5
Potential therapeutic uses of mecamylamine and its stereoisomers.美加明及其对映异构体的潜在治疗用途。
Pharmacol Biochem Behav. 2013 Jul;108:28-43. doi: 10.1016/j.pbb.2013.04.005. Epub 2013 Apr 18.
6
Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual.骨骼副交感神经支配传递中枢 IL-1 信号,调节骨量积累。
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15455-60. doi: 10.1073/pnas.1206061109. Epub 2012 Sep 4.
7
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.烟碱型乙酰胆碱受体拮抗模式:尼古丁辨别研究。
J Pharmacol Exp Ther. 2011 Oct;339(1):194-202. doi: 10.1124/jpet.111.182170. Epub 2011 Jul 5.
8
Acute nicotine increases both impulsive choice and behavioural disinhibition in rats.急性尼古丁增加大鼠的冲动选择和行为抑制。
Psychopharmacology (Berl). 2011 Oct;217(4):455-73. doi: 10.1007/s00213-011-2296-2. Epub 2011 Apr 19.
9
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.神经元烟碱型乙酰胆碱受体作为治疗酒精使用障碍的药物治疗靶点。
CNS Neurol Disord Drug Targets. 2010 Mar;9(1):60-76. doi: 10.2174/187152710790966597.
10
Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse.促肾上腺皮质激素释放因子-1受体激活介导尼古丁戒断诱导的大脑奖赏功能缺陷及应激诱导的复吸。
Biol Psychiatry. 2009 Jul 15;66(2):110-7. doi: 10.1016/j.biopsych.2009.01.010. Epub 2009 Feb 12.