Krivopalov S A, Yushkov B G
Zh Vyssh Nerv Deiat Im I P Pavlova. 2015 Nov-Dec;65(6):756-65.
In the "open field" test it was found that locomotor activity in Krushinsky-Molodkina rat strain (KM) is higher than in nonlinear animals. At the same time, both groups of animals had the same sex differences: a locomotor activity of females was higher than males. Sex differences in exploratory activities are not inherent for KM rats, while the female outbred animals are significantly higher than males in their level of such activities. The greatest differences in behavior between KM rats and outbred animals were found in anxiety level, which is much higher in the first case. Furthermore just KM rats are characterized by clear sex differences--the males demonstrate more anxious and fearful respond to unfamiliar surroundings than females. Male and female KM rats differ not only in behavior but also in the character of epileptiform seizures induced by loud sound: wild running, tonic-clonic and clonic convulsions occur faster in females and the resumption of breathing-in males. The interconnection between parameters of seizure and behavior was found for KM rats. This phenomenon is most clearly manifested in males and combine large group of indicators.
在“旷场”试验中发现，克鲁申斯基 - 莫洛金娜大鼠品系（KM）的运动活性高于非品系动物。同时，两组动物都存在相同的性别差异：雌性的运动活性高于雄性。探索活动中的性别差异并非KM大鼠所固有，而雌性远交动物在这种活动水平上显著高于雄性。KM大鼠与远交动物在行为上的最大差异体现在焦虑水平上，前者的焦虑水平要高得多。此外，只有KM大鼠具有明显的性别差异——雄性对陌生环境表现出比雌性更焦虑和恐惧的反应。雄性和雌性KM大鼠不仅在行为上存在差异，而且在由大声响诱发的癫痫样发作特征上也有所不同：雌性出现狂奔、强直 - 阵挛和阵挛性惊厥的速度更快，而雄性恢复呼吸的速度更快。在KM大鼠中发现了癫痫发作参数与行为之间的相互联系。这种现象在雄性中表现得最为明显，并涉及大量指标。
