BA11 FKBP5表达水平与创伤后应激障碍（PTSD）患者及对照者尸检大脑中的树突棘密度相关。
BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls.
作者信息
Young Keith A, Thompson Peter M, Cruz Dianne A, Williamson Douglas E, Selemon Lynn D
机构信息
Central Texas Veterans Health Care System, Temple, TX, USA; Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA; Department of Psychiatry and Behavioral Science, Texas A&M Health Science Center, Temple, TX, USA.
Department of Psychiatry and Southwest Brain Bank, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
出版信息
Neurobiol Stress. 2015 Sep 3;2:67-72. doi: 10.1016/j.ynstr.2015.07.002. eCollection 2015.
Genetic variants of the immunophilin FKBP5 have been implicated in susceptibility to post-traumatic stress disorder (PTSD) and other stress-related disorders. We examined the relationship between mushroom, stubby, thin and filopodial spine densities measured with Golgi staining and FKBP5 gene expression in the medial orbitofrontal cortex (BA11) in individuals diagnosed with PTSD and normal controls (n = 8/8). ANCOVA revealed PTSD cases had a significantly elevated density of stubby spines (29%, P < 0.037) and a trend for a reduction in mushroom spine density (25%, p < 0.082). Levels of FKBP5 mRNA were marginally elevated in the PTSD cases (z = 1.94, p = 0.053) and levels correlated inversely with mushroom (Spearman's rho = -0.83, p < 0.001) and overall spine density (rho = -0.75, p < 0.002) and directly with stubby spine density (rho = 0.55, p < 0.027). These data suggest that FKBP5 may participate in a cellular pathway modulating neuronal spine density changes in the brain, and that this pathway may be dysregulated in PTSD.
免疫亲和蛋白FKBP5的基因变异与创伤后应激障碍（PTSD）及其他应激相关障碍的易感性有关。我们检测了通过高尔基染色测量的蘑菇状、短粗状、细状和丝状棘突密度与PTSD患者及正常对照者（n = 8/8）眶额内侧皮质（BA11）中FKBP5基因表达之间的关系。协方差分析显示，PTSD患者短粗状棘突的密度显著升高（29%，P < 0.037），蘑菇状棘突密度有降低趋势（25%，p < 0.082）。PTSD患者中FKBP5 mRNA水平略有升高（z = 1.94，p = 0.053），且该水平与蘑菇状棘突（斯皮尔曼相关系数rho = -0.83，p < 0.001）及总体棘突密度（rho = -0.75，p < 0.002）呈负相关，与短粗状棘突密度呈正相关（rho = 0.55，p < 0.027）。这些数据表明，FKBP5可能参与调节大脑中神经元棘突密度变化的细胞途径，并提示该途径在PTSD中可能失调。
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