Clausen Maja-Lisa, Agner Tove
Curr Probl Dermatol. 2016;49:38-46. doi: 10.1159/000441543. Epub 2016 Feb 4.
The skin serves as a strong barrier protecting us from invading pathogens and harmful organisms. An important part of this barrier comes from antimicrobial peptides (AMPs), which are small peptides expressed abundantly in the skin. AMPs are produced in the deeper layers of the epidermis and transported to the stratum corneum, where they play a vital role in the first line of defense against potential pathogens. Numerous AMPs exist, and they have a broad antibiotic-like activity against bacteria, fungi and viruses. They also act as multifunctional effector molecules, linking innate and adaptive immune responses. AMPs play an essential part in maintaining an optimal and functional skin barrier - not only by direct killing of pathogens, but also by balancing immune responses and interfering in wound healing, cell differentiation, reepithelialization and their synergistic interplay with the skin microflora.
皮肤是一道强大的屏障，保护我们免受入侵病原体和有害生物的侵害。这道屏障的一个重要组成部分来自抗菌肽（AMPs），它们是在皮肤中大量表达的小肽。抗菌肽在表皮深层产生，并运输到角质层，在那里它们在抵御潜在病原体的第一道防线中发挥着至关重要的作用。存在多种抗菌肽，它们对细菌、真菌和病毒具有广泛的类抗生素活性。它们还作为多功能效应分子，连接先天免疫和适应性免疫反应。抗菌肽在维持最佳和功能性皮肤屏障方面发挥着重要作用——不仅通过直接杀死病原体，还通过平衡免疫反应、干扰伤口愈合、细胞分化、再上皮化以及它们与皮肤微生物群的协同相互作用。
