Division of Dermatology, Department of Medicine, University of California at San Diego and VA San Diego Health Care System, San Diego, California, USA.
J Invest Dermatol. 2011 Feb;131(2):285-7. doi: 10.1038/jid.2010.360.
Antimicrobial peptides (AMPs) are an essential and multifunctional element for immune defense of the skin during infection and injury. In this issue, Ahrens et al. characterize the response of β-defensins, a class of AMPs, following acute and chronic challenges to the permeability barrier of the skin. Their findings suggest that the antimicrobial and permeability barriers of the skin are closely linked.
抗菌肽（AMPs）是感染和损伤时皮肤免疫防御的重要且多功能的组成部分。在本期杂志中，Ahrens 等人描述了在皮肤通透性屏障受到急性和慢性挑战后，β-防御素（一类 AMPs）的反应。他们的研究结果表明，皮肤的抗菌和通透性屏障密切相关。
