Lou Jiaqi, Xiang Ziyi, Zhu Xiaoyu, Li Jiliang, Jin Guoying, Cui Shengyong, Huang Neng, Le Xin, Fan Youfen, Sun Qionghui
Burn Department, Ningbo No.2 Hospital, Ningbo, China.
Institute of Pathology, Faculty of Medicine, University of Bonn, Bonn, Germany.
Front Microbiol. 2025 Jul 1;16:1575081. doi: 10.3389/fmicb.2025.1575081. eCollection 2025.
Skin microbiota is the microbial population on the skin surface, which has a symbiotic relationship with the host skin and plays an important role in maintaining skin health and regulating immune responses. In patients with diabetic foot ulcers (DFUs), the skin microbiota is unbalanced. The abundance of pathogenic bacteria such as and increases, forming biofilms, destroying the skin barrier function, aggravating infection, and leading to poor wound healing. Studies have shown that the diversity of skin microbiota is positively correlated with the severity of ulcers, and regulating its composition and function may be an important strategy to improve DFUs healing. In recent years, with the development of molecular biology technology, progress has been made in the study of skin microbiota, such as 16S rRNA gene sequencing technology to understand its composition changes and explore the interaction mechanism with the host immune system. Based on this, some new therapeutic approaches are being explored, such as the use of probiotics or antibacterial drugs to modulate the composition of the microbiota and the development of microbiota-based personalized treatment regimens. However, there are still challenges in current research. For example, the composition and function of skin microbiota are affected by many factors, and there are relatively few studies on other microorganisms such as fungi and viruses. In the future, it is necessary to further explore its diversity and the interaction mechanism with the host, and develop more effective treatment methods to improve the prognosis of patients with DFUs.
皮肤微生物群是皮肤表面的微生物群体，它与宿主皮肤存在共生关系，在维持皮肤健康和调节免疫反应方面发挥着重要作用。在糖尿病足溃疡（DFU）患者中，皮肤微生物群失衡。诸如[此处原文缺失具体细菌名称]等病原菌的丰度增加，形成生物膜，破坏皮肤屏障功能，加重感染，并导致伤口愈合不良。研究表明，皮肤微生物群的多样性与溃疡的严重程度呈正相关，调节其组成和功能可能是改善DFU愈合的重要策略。近年来，随着分子生物学技术的发展，皮肤微生物群的研究取得了进展，例如利用16S rRNA基因测序技术了解其组成变化并探索与宿主免疫系统的相互作用机制。基于此，正在探索一些新的治疗方法，如使用益生菌或抗菌药物来调节微生物群的组成以及开发基于微生物群的个性化治疗方案。然而，当前研究仍面临挑战。例如，皮肤微生物群的组成和功能受多种因素影响，而对真菌和病毒等其他微生物的研究相对较少。未来，有必要进一步探索其多样性以及与宿主的相互作用机制，并开发更有效的治疗方法以改善DFU患者的预后。
