Nabavi Seyed Fazel, Braidy Nady, Habtemariam Solomon, Sureda Antoni, Manayi Azadeh, Nabavi Seyed Mohammad
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran.
Curr Top Med Chem. 2016;16(17):1910-5. doi: 10.2174/1568026616666160204121725.
According to the epidemiological reports published by the World Health Organization, the proportion of elderly people (over 60 years) will increase from 11% to 22% by 2050 worldwide. This increase will be associated with a growing rate of morbidity and mortality of age-related diseases. Mental and neurodegenerative diseases are important health problems in elderly people. Therefore, recent research has been focused on finding effective neuroprotective agents with low adverse effects. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel therapeutic agents for treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Among them, flavonoid chemical class is known as one of the most bioactive and non-toxic phytochemicals, which are widely found in different herbal medicines and edible plants. Fisetin is one of the most common and bioactive flavonoids which possesses potential neuroprotective effects. Fisetin also enhances learning and memory, decreases neuronal cell death, and suppresses oxidative stress. The present paper aims to critically evaluate the available literature regarding the beneficial effects of fisetin on neurodegenerative diseases, especially AD and PD. In addition, we provide information regarding the chemistry, sources, bioavailability and clinical impacts of fisetin to provide a broad spectrum for the use of this compound as a new approach to the treatment of AD and PD.
根据世界卫生组织发布的流行病学报告，到2050年，全球60岁以上老年人的比例将从11%增至22%。这一增长将与年龄相关疾病的发病率和死亡率上升相关。精神和神经退行性疾病是老年人的重要健康问题。因此，近期研究聚焦于寻找副作用小的有效神经保护剂。在过去二十年里，植物源生物活性化合物作为治疗阿尔茨海默病（AD）和帕金森病（PD）等神经退行性疾病的新型治疗剂受到了广泛关注。其中，黄酮类化合物是已知生物活性最强且无毒的植物化学物质之一，广泛存在于不同的草药和可食用植物中。非瑟酮是最常见且具有生物活性的黄酮类化合物之一，具有潜在的神经保护作用。非瑟酮还能增强学习和记忆能力，减少神经元细胞死亡，并抑制氧化应激。本文旨在批判性地评估现有文献中关于非瑟酮对神经退行性疾病，尤其是AD和PD有益作用的研究。此外，我们提供了有关非瑟酮的化学性质、来源、生物利用度和临床影响的信息，为将该化合物用作治疗AD和PD的新方法提供广泛依据。
