Braidy Nady, Behzad Sahar, Habtemariam Solomon, Ahmed Touqeer, Daglia Maria, Nabavi Seyed Mohammad, Sobarzo-Sanchez Eduardo, Nabavi Seyed Fazel
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney. Australia.
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
CNS Neurol Disord Drug Targets. 2017;16(4):387-397. doi: 10.2174/1871527316666170328113309.
Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease represent a deleterious impact worldwide. Despite extensive preclinical and clinical research in neurodegenerative disorders, therapeutic strategies aimed at the prevention and chronic treatment of neurodegenerative conditions have not been successfully translated to the clinic. Therefore, the identification of novel pharmacological intervention derived from natural products is warranted. Nobiletin and tangeretin are important citrus flavonoids derived from the peel and other parts of Citrus L. genus, and have been shown to exhibit neuroprotective effects in several in vitro and in vivo studies. Apart from there antioxidant and anti-inflammatory effects, nobiletin and tangeretin have been shown to attenuate cholinergic deficits, reduce the abnormal accumulation of neurotoxic amyloid-beta peptides, reverse N-methyl- D-aspartate (NMDA) receptor hypofunction, ameliorate ischemic injury, inhibit hyperphosphorylation of tau protein, enhance neprilysin levels, modulate several signaling cascades, and protect against 1-methyl-4-phenylpyridinium (MPP(+)) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity. Taken together, these naturally occurring phytochemicals may represent beneficial drug candidates for the treatment and prevention of Alzheimer's and Parkinson's disease.
神经退行性疾病，即阿尔茨海默病和帕金森病，在全球范围内造成了有害影响。尽管在神经退行性疾病方面进行了广泛的临床前和临床研究，但旨在预防和长期治疗神经退行性疾病的治疗策略尚未成功转化为临床应用。因此，有必要从天然产物中鉴定新的药物干预措施。川陈皮素和橘皮素是从柑橘属植物的果皮和其他部位提取的重要柑橘类黄酮，并且在多项体外和体内研究中已显示出具有神经保护作用。除了具有抗氧化和抗炎作用外，川陈皮素和橘皮素还被证明可减轻胆碱能缺陷、减少神经毒性淀粉样β肽的异常积累、逆转N-甲基-D-天冬氨酸（NMDA）受体功能低下、改善缺血性损伤、抑制tau蛋白的过度磷酸化、提高中性内肽酶水平、调节多种信号级联反应，并防止1-甲基-4-苯基吡啶鎓（MPP(+)）和1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）毒性。综上所述，这些天然存在的植物化学物质可能是治疗和预防阿尔茨海默病和帕金森病的有益候选药物。
