Kiseleva T N, Zol'nikova I V, Demenkova O N, Ramazanova K A, Egorova I V, Rogatina E V, Rogova S Yu, Kiseleva T N, Zol'nikova I V, Demenkova O N, Ramazanova K A, Egorova I V, Rogatina E V, Rogova S Yu
Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
Vestn Oftalmol. 2015 Sep-Oct;131(5):14-19. doi: 10.17116/oftalma2015131514-19.
to investigate correlations between changes in ocular hemodynamics revealed by color Doppler flow mapping (CDFM) and pulsed-wave (PW) Doppler imaging, one the one hand, and electrical activity of the retina, on the other, in patients with early, moderate, and severe retinitis pigmentosa (RP).
A total of 20 patients (40 eyes) aged from 16 to 40 years (28.4 ± 8.2 years on average) with retinitis pigmentosa were enrolled. The control group consisted of 20 healthy volunteers of the same age range. All participants underwent full-field electroretinography (ERG), flicker ERG, and macular ERG as well as blood flow assessment in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCA) by means of CDFM and PW-Doppler.
Ocular blood flow in CRA and SPCA appeared disturbed in patients with early RP. In cases of moderate and severe RP, the peak systolic velocity of CRA and SPCA blood flow was significantly decreased. Systolic and end diastolic blood flow velocities in CRA and SPCA has been shown to be directly related to full-field ERG a-wave and b-wave amplitudes, correspondingly, but negatively correlated with their implicit times.
The revealed decrease in CRA and SPCA blood flow indices proves retinal and choroidal circulation deficit in patients with advanced RP. As shown, moderate blood flow changes are already present in early RP and progress as retinal photoreceptors and bipolar cells become suppressed, which may be useful for RP diagnosis and monitoring.
研究彩色多普勒血流成像（CDFM）和脉冲波（PW）多普勒成像所揭示的眼部血流动力学变化与早期、中度和重度视网膜色素变性（RP）患者视网膜电活动之间的相关性。
共纳入20例年龄在16至40岁（平均28.4±8.2岁）的视网膜色素变性患者（40只眼）。对照组由20名年龄范围相同的健康志愿者组成。所有参与者均接受了全视野视网膜电图（ERG）、闪烁ERG和黄斑ERG检查，以及通过CDFM和PW多普勒对眼动脉（OA）、视网膜中央动脉（CRA）和睫状后短动脉（SPCA）进行血流评估。
早期RP患者的CRA和SPCA眼部血流出现紊乱。在中度和重度RP患者中，CRA和SPCA血流的收缩期峰值速度显著降低。已表明CRA和SPCA的收缩期和舒张末期血流速度分别与全视野ERG的a波和b波振幅直接相关，但与它们的潜伏时间呈负相关。
所揭示的CRA和SPCA血流指数降低证明晚期RP患者存在视网膜和脉络膜循环不足。结果表明，早期RP患者已经出现中度血流变化，并且随着视网膜光感受器和双极细胞受到抑制而进展，这可能对RP的诊断和监测有用。
