视网膜色素变性中视网膜血流减少。
Decreased retinal blood flow in retinitis pigmentosa.
作者信息
Akyol N, Kükner S, Celiker U, Koyu H, Lüleci C
机构信息
Department of Ophthalmology, First University School of Medicine, Elazig, Turkey.
出版信息
Can J Ophthalmol. 1995 Feb;30(1):28-32.
OBJECTIVE
To determine alterations in retinal blood flow in retinitis pigmentosa (RP).
DESIGN
Case-control study.
SETTING
Ophthalmology department of a university-affiliated hospital in Elazig, Turkey.
SUBJECTS
Ten patients (20 eyes) with typical RP and 22 age-matched volunteer subjects (22 eyes) with no history of ocular or systemic disease.
MAIN OUTCOME MEASURES
Central retinal artery peak systolic and diastolic blood flow velocity (measured by means of colour Doppler imaging), resistance index and pulsatility index.
RESULTS
The mean peak systolic and diastolic flow velocity values were significantly lower in the study group than in the control group (4.96 +/- 1.3 vs. 11.11 +/- 1.5 cm/s [p < 0.00001] and 2.15 +/- 0.4 vs. 3.40 +/- 0.9 cm/s [p < 0.0001] respectively). The mean resistance index value was significantly lower in the study group (0.55 +/- 0.05) than in the control group (0.71 +/- 0.06) (p < 0.0001), as was the mean pulsatility index value (0.94 +/- 0.18 vs. 1.45 +/- 0.36) (p < 0.00001).
CONCLUSIONS
Decreased retinal blood flow is an important feature of RP.
目的
确定视网膜色素变性（RP）患者视网膜血流的改变情况。
设计
病例对照研究。
地点
土耳其埃拉泽格一所大学附属医院的眼科。
研究对象
10例典型RP患者（20只眼）和22名年龄匹配的无眼部或全身性疾病史的志愿者（22只眼）。
主要观察指标
视网膜中央动脉收缩期和舒张期血流峰值速度（通过彩色多普勒成像测量）、阻力指数和搏动指数。
结果
研究组的平均收缩期和舒张期血流峰值速度值显著低于对照组（分别为4.96±1.3与11.11±1.5 cm/s [p<0.00001]和2.15±0.4与3.40±0.9 cm/s [p<0.0001]）。研究组的平均阻力指数值（0.55±0.05）显著低于对照组（0.71±0.06）（p<0.0001），平均搏动指数值也是如此（0.94±0.18与1.45±0.36）（p<0.00001）。
结论
视网膜血流减少是RP的一个重要特征。
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