通过光学相干断层扫描血管造影评估不同类型遗传性视网膜营养不良中的视网膜血管异常。
Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography.
作者信息
Sabbaghi Hamideh, Daftarian Narsis, Hassanpour Kiana, Fekri Sahba, Nourinia Ramin, Suri Fatemeh, Kheiri Bahareh, Yaseri Mehdi, Rajabpour Mojtaba, Sheibani Kourosh, Ahmadieh Hamid
机构信息
Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
J Curr Ophthalmol. 2021 Jul 5;33(2):189-196. doi: 10.4103/joco.joco_11_21. eCollection 2021 Apr-Jun.
PURPOSE
To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs).
METHODS
This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IRD including 37 patients with retinitis pigmentosa (RP) (74 eyes), 13 patients with Stargardt disease (STGD) (26 eyes), and 9 patients with cone-rod dystrophy (CRD) (18 eyes). Both eyes of 50 age- and sex-matched healthy individuals were investigated as controls. All participants underwent optical coherence tomography angiography to investigate the vascular densities (VDs) of superficial and deep capillary plexus (SCP and DCP) as well as foveal avascular zone area.
RESULTS
In RP, significantly lower VD in whole image ( = 0.001 for DCP), fovea ( = 0.038 for SCP), parafovea ( < 0.001 for SCP and DCP), and perifovea ( < 0.001 for SCP and DCP) was observed compared to controls. In STGD, VD of parafovea ( = 0.012 for SCP and = 0.001 for DCP) and fovea ( = 0.016 for DCP) was significantly lower than controls. In CRD, the VD of parafovea ( = 0.025 for DCP) was significantly lower than controls. Whole image density was significantly lower in RP compared to STGD ( < 0.001 for SCP) and CRD ( = 0.037 for SCP). VD in parafovea ( = 0.005 for SCP) and perifovea ( < 0.001 for SCP and DCP) regions was significantly lower in RP compared with STGD. Also, foveal VD in STGD was significantly lower than RP ( = 0.023 for DCP).
CONCLUSION
Our study demonstrated lower VDs in three different IRDs including RP, STGD, and CRD compared to healthy controls. Changes were more dominant in RP patients.
目的
研究不同类型遗传性视网膜营养不良（IRD）患者的视网膜血管特征。
方法
本比较性横断面研究纳入了59例经基因确诊的IRD患者，其中包括37例视网膜色素变性（RP）患者（74只眼）、13例斯特格氏病（STGD）患者（26只眼）和9例锥杆营养不良（CRD）患者（18只眼）。将50名年龄和性别匹配的健康个体的双眼作为对照进行研究。所有参与者均接受光学相干断层扫描血管造影，以研究浅表和深层毛细血管丛（SCP和DCP）的血管密度（VD）以及黄斑无血管区面积。
结果
与对照组相比，RP患者在整个图像（DCP， = 0.001）、黄斑（SCP， = 0.038）、黄斑旁（SCP和DCP， < 0.001）和黄斑周围（SCP和DCP， < 0.001）的VD显著降低。在STGD患者中，黄斑旁（SCP， = 0.012；DCP， = 0.001）和黄斑（DCP， = 0.016）的VD显著低于对照组。在CRD患者中，黄斑旁（DCP， = 0.025）的VD显著低于对照组。与STGD（SCP， < 0.001）和CRD（SCP， = 0.037）相比，RP患者的整个图像密度显著降低。与STGD相比，RP患者黄斑旁（SCP， = 0.005）和黄斑周围（SCP和DCP， < 0.001）区域的VD显著降低。此外，STGD患者的黄斑VD显著低于RP患者（DCP， = 0.023）。
结论
我们的研究表明，与健康对照组相比，RP、STGD和CRD这三种不同的IRD患者的VD较低。RP患者的变化更为明显。
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