From the Wihuri Research Institute (A.A., M.R.R., S.K., K.A.) and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (A.A., M.R.R., K.A.); and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (T.M.).
Circ Res. 2016 Feb 5;118(3):515-30. doi: 10.1161/CIRCRESAHA.115.306544.
The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation. The cardinal manifestation of lymphatic malfunction is lymphedema. Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular diseases including obesity and metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction. Here, we review the most recent advances in the field of lymphatic vascular biology, with a focus on cardiovascular disease.
哺乳动物的循环系统包括心血管系统和淋巴系统。与血液血管循环不同，淋巴系统形成从细胞外空间到静脉系统的单向转运途径。它主动调节组织液稳态、胃肠道脂质的吸收以及抗原呈递细胞和淋巴细胞向淋巴器官以及全身循环的运输。淋巴功能障碍的主要表现是淋巴水肿。最近的研究表明，淋巴系统与心血管疾病的发病机制有关，包括肥胖和代谢疾病、血脂异常、炎症、动脉粥样硬化、高血压和心肌梗死。在这里，我们综述了淋巴血管生物学领域的最新进展，重点是心血管疾病。
