Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Int J Mol Sci. 2020 Jul 6;21(13):4790. doi: 10.3390/ijms21134790.
The lymphatic vasculature, along with the blood vasculature, is a vascular system in our body that plays important functions in fluid homeostasis, dietary fat uptake, and immune responses. Defects in the lymphatic system are associated with various diseases such as lymphedema, atherosclerosis, fibrosis, obesity, and inflammation. The first step in lymphangiogenesis is determining the cell fate of lymphatic endothelial cells. Several genes involved in this commitment step have been identified using animal models, including genetically modified mice. This review provides an overview of these genes in the mammalian system and related human diseases.
淋巴管系统与血管系统一起，是我们身体中的一个血管系统，在体液平衡、膳食脂肪吸收和免疫反应中发挥着重要作用。淋巴管系统的缺陷与各种疾病有关，如淋巴水肿、动脉粥样硬化、纤维化、肥胖和炎症。淋巴管生成的第一步是确定淋巴管内皮细胞的细胞命运。已经使用动物模型鉴定了几个涉及这一承诺步骤的基因，包括基因修饰小鼠。这篇综述概述了哺乳动物系统中的这些基因以及相关的人类疾病。
