Meyberg-Solomayer Gabriele, Hamza Amr, Takacs Zoltan, Leingartner Anika, Radosa Julia, Joukhadar Ralf, Juhasz-Böss Ingolf, Solomayer Erich-Franz
Department of Gynecology and Obstetrics, Saarland University Hospital, Homburg, Germany.
Prenat Diagn. 2016 Apr;36(4):332-7. doi: 10.1002/pd.4785. Epub 2016 Feb 28.
The objective of this study is to examine the association of lateral fetal neck cysts with increased nuchal translucency, chromosomal abnormalities and fetal malformations.
In a consecutive collective of 4216 prenatal ultrasound examinations between 11 and 17 weeks of gestation 32 fetuses with lateral neck cysts were found. The size of the cysts was examined. The association of the findings with increased nuchal translucency, chromosomal aberrations and fetal malformations was examined.
All but two out of 32 cases had bilateral cysts. Seventeen fetuses had aneuploidy and an increased nuchal translucency, 15 of those with major structural malformations. Of the 15 fetuses with normal karyotype nine (60%) had an increased nuchal translucency, seven had a fetal malformation or hydrops. A favorable outcome was found in 6/15 fetuses with normal karyotype and normal nuchal translucency. Lateral neck cyst diameter was associated to nuchal translucency, chromosomal abnormality and/or fetal malformations. Cysts smaller than 3 mm had a favorable outcome even in the presence of an increased nuchal translucency.
Fetuses with lateral neck cysts often not only present with increased nuchal translucency and chromosomal aberrations but also with fetal malformations. Fetuses with lateral neck cysts and increased nuchal translucency were aneuploid or had a fetal malformation in 85%. Cysts smaller than 3 mm had a favorable outcome. © 2016 John Wiley & Sons, Ltd.
本研究的目的是探讨胎儿颈部侧方囊肿与颈项透明层增厚、染色体异常及胎儿畸形之间的关联。
在连续4216例妊娠11至17周的产前超声检查中，发现32例胎儿有颈部侧方囊肿。检查囊肿大小，并研究这些发现与颈项透明层增厚、染色体畸变及胎儿畸形之间的关联。
32例病例中除2例之外均为双侧囊肿。17例胎儿存在非整倍体及颈项透明层增厚，其中15例伴有严重结构畸形。在15例核型正常的胎儿中，9例（60%）有颈项透明层增厚，7例有胎儿畸形或水肿。15例核型正常且颈项透明层正常的胎儿中有6例预后良好。颈部侧方囊肿直径与颈项透明层增厚、染色体异常和/或胎儿畸形有关。即使存在颈项透明层增厚，直径小于3mm的囊肿预后良好。
有颈部侧方囊肿的胎儿不仅常伴有颈项透明层增厚和染色体畸变，还伴有胎儿畸形。有颈部侧方囊肿且颈项透明层增厚的胎儿中，85%存在非整倍体或胎儿畸形。直径小于3mm的囊肿预后良好。©2016约翰威立父子有限公司
